PDB entry 3l3t

View 3l3t on RCSB PDB site
Description: Human mesotrypsin complexed with amyloid precursor protein inhibitor variant (APPIR15K)
Class: Hydrolase/Cell Adhesion
Keywords: Human mesotrypsin, Canonical inhibitor, Alzheimer's amyloid precursor protein inhibitor,APPI, APPI-R15K, Hydrolase-Cell Adhesion complex
Deposited on 2009-12-17, released 2010-09-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-01-12, with a file datestamp of 2011-01-07.
Experiment type: XRAY
Resolution: 2.38 Å
R-factor: 0.183
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: PRSS3 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: PRSS3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8N2U3 (0-223)
      • engineered mutation (176)
    Domains in SCOPe 2.07: d3l3ta_
  • Chain 'B':
    Compound: PRSS3 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: PRSS3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8N2U3 (0-223)
      • engineered mutation (176)
    Domains in SCOPe 2.07: d3l3tb_
  • Chain 'C':
    Compound: PRSS3 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: PRSS3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8N2U3 (0-223)
      • engineered mutation (176)
    Domains in SCOPe 2.07: d3l3tc_
  • Chain 'D':
    Compound: PRSS3 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: PRSS3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8N2U3 (0-223)
      • engineered mutation (176)
    Domains in SCOPe 2.07: d3l3td_
  • Chain 'E':
    Compound: Protein APP
    Species: Homo sapiens [TaxId:9606]
    Gene: APP
    Database cross-references and differences (RAF-indexed):
    • Uniprot C9JHU0 (0-56)
      • engineered mutation (12)
    Domains in SCOPe 2.07: d3l3te_
  • Chain 'F':
    Compound: Protein APP
    Species: Homo sapiens [TaxId:9606]
    Gene: APP
    Database cross-references and differences (RAF-indexed):
    • Uniprot C9JHU0 (0-56)
      • engineered mutation (12)
    Domains in SCOPe 2.07: d3l3tf_
  • Chain 'G':
    Compound: Protein APP
    Species: Homo sapiens [TaxId:9606]
    Gene: APP
    Database cross-references and differences (RAF-indexed):
    • Uniprot C9JHU0 (0-56)
      • engineered mutation (12)
    Domains in SCOPe 2.07: d3l3tg_
  • Chain 'H':
    Compound: Protein APP
    Species: Homo sapiens [TaxId:9606]
    Gene: APP
    Database cross-references and differences (RAF-indexed):
    • Uniprot C9JHU0 (0-56)
      • engineered mutation (12)
    Domains in SCOPe 2.07: d3l3th_
  • Heterogens: FMT, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3l3tA (A:)
ivggytceenslpyqvslnsgshfcggsliseqwvvsaahcyktriqvrlgehnikvleg
neqfinaakiirhpkynrdtldndimliklsspavinarvstislptappaagteclisg
wgntlsfgadypdelkcldapvltqaeckasypgkitnsmfcvgfleggkdscqrdaggp
vvcngqlqgvvswghgcawknrpgvytkvynyvdwikdtiaans

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3l3tB (B:)
ivggytceenslpyqvslnsgshfcggsliseqwvvsaahcyktriqvrlgehnikvleg
neqfinaakiirhpkynrdtldndimliklsspavinarvstislptappaagteclisg
wgntlsfgadypdelkcldapvltqaeckasypgkitnsmfcvgfleggkdscqrdaggp
vvcngqlqgvvswghgcawknrpgvytkvynyvdwikdtiaans

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3l3tC (C:)
ivggytceenslpyqvslnsgshfcggsliseqwvvsaahcyktriqvrlgehnikvleg
neqfinaakiirhpkynrdtldndimliklsspavinarvstislptappaagteclisg
wgntlsfgadypdelkcldapvltqaeckasypgkitnsmfcvgfleggkdscqrdaggp
vvcngqlqgvvswghgcawknrpgvytkvynyvdwikdtiaans

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3l3tD (D:)
ivggytceenslpyqvslnsgshfcggsliseqwvvsaahcyktriqvrlgehnikvleg
neqfinaakiirhpkynrdtldndimliklsspavinarvstislptappaagteclisg
wgntlsfgadypdelkcldapvltqaeckasypgkitnsmfcvgfleggkdscqrdaggp
vvcngqlqgvvswghgcawknrpgvytkvynyvdwikdtiaans

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3l3tE (E:)
evcseqaetgpckamisrwyfdvtegkcapffyggcggnrnnfdteeycmavcgsai

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3l3tF (F:)
evcseqaetgpckamisrwyfdvtegkcapffyggcggnrnnfdteeycmavcgsai

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3l3tG (G:)
evcseqaetgpckamisrwyfdvtegkcapffyggcggnrnnfdteeycmavcgsai

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3l3tH (H:)
evcseqaetgpckamisrwyfdvtegkcapffyggcggnrnnfdteeycmavcgsai