PDB entry 3kz8

View 3kz8 on RCSB PDB site
Description: Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 3)
Class: transcription/DNA
Keywords: P53, mutant protein, loop-sheet-helix motif, DNA target, activator, ANTI-oncogene apoptosis, cell cycle, covalent protein-rna linkage, disease mutation, DNA-binding, endoplasmic reticulum, glycoprotein, host-virus interaction, LI-fraumeni syndrome, methylation, nucleus, phosphoprotein, transcription, transcription regulation, transcription/dna comple, apoptosis, isopeptide bond, tumor suppressor, TRANSCRIPTION-DNA complex
Deposited on 2009-12-08, released 2010-03-31
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-06-08, with a file datestamp of 2011-06-03.
Experiment type: XRAY
Resolution: 1.91 Å
R-factor: 0.223
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3kz8a_
  • Chain 'B':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3kz8b_
  • Chain 'C':
    Compound: DNA (5'-d(*tp*gp*gp*gp*cp*ap*tp*gp*cp*cp*cp*gp*gp*gp*cp*ap*tp*gp*cp*cp*c)-3')
    Species: synthetic, synthetic
  • Heterogens: ZN, IOD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3kz8A (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevr
vcacpgrdrrteeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >3kz8A (A:)
ssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppg
trvramaiykqsqhmtevvrrcphhercsdlappqhlirvegnlrveylddrntfrhsvv
vpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevrvcac
pgrdrrteeenlrkk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3kz8B (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevr
vcacpgrdrrteeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >3kz8B (B:)
ssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppg
trvramaiykqsqhmtevvrrcphhercsdlappqhlirvegnlrveylddrntfrhsvv
vpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevrvcac
pgrdrrteeenlrkk

  • Chain 'C':
    No sequence available.