PDB entry 3kz1

View 3kz1 on RCSB PDB site
Description: Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA
Class: signaling protein
Keywords: regulation of RhoA GTPase, RhoGEF, DH, PH, Rho, GTPase activation, Guanine-nucleotide releasing factor, Membrane, Cytoskeleton, GTP-binding, Magnesium, Nucleotide-binding, Prenylation, Proto-oncogene, signaling protein
Deposited on 2009-12-07, released 2010-04-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.236
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Rho guanine nucleotide exchange factor 11
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGEF11, KIAA0380
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3kz1a1, d3kz1a2
  • Chain 'B':
    Compound: Rho guanine nucleotide exchange factor 11
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGEF11, KIAA0380
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3kz1b1, d3kz1b2
  • Chain 'E':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARH12, ARHA, RHO12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3kz1e_
  • Chain 'F':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARH12, ARHA, RHO12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3kz1f_
  • Heterogens: MG, GSP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3kz1A (A:)
    gepdaqnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkken
    lmpreelarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqv
    aaqfcsyqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkypll
    lesiikhteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalera
    snplaaefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkch
    sktavgssdskqtfspvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkn
    twmelleeavrnatrhphhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >3kz1A (A:)
    qnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpre
    elarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqfc
    syqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesii
    khteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpla
    aefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkchskqtf
    spvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwmelleeavrnat
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3kz1B (B:)
    gepdaqnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkken
    lmpreelarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqv
    aaqfcsyqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkypll
    lesiikhteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalera
    snplaaefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkch
    sktavgssdskqtfspvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkn
    twmelleeavrnatrhphhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >3kz1B (B:)
    nwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpree
    larlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqfcs
    yqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesiik
    hteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnplaa
    efksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkchsktfsp
    vlklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwmelleeavrna
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >3kz1E (E:)
    gmaairkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelalwd
    tagqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkk
    dlrndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraal
    qa
    

    Sequence, based on observed residues (ATOM records): (download)
    >3kz1E (E:)
    airkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelalwdtag
    qedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlr
    ndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalqa
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >3kz1F (F:)
    gmaairkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelalwd
    tagqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkk
    dlrndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraal
    qa
    

    Sequence, based on observed residues (ATOM records): (download)
    >3kz1F (F:)
    airkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelalwdtag
    qedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlr
    ndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalqa