PDB entry 3kx1

View 3kx1 on RCSB PDB site
Description: Cathepsin K in complex with a selective 2-cyano-pyrimidine inhibitor
Class: hydrolase
Keywords: cathepsin K, enzyme inhibitor, covalent reversible inhibitor, Disease mutation, Disulfide bond, Glycoprotein, Hydrolase, Lysosome, Protease, Thiol protease, Zymogen
Deposited on 2009-12-02, released 2010-03-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-02-12, with a file datestamp of 2014-02-07.
Experiment type: XRAY
Resolution: 1.51 Å
R-factor: 0.243
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cathepsin k
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3kx1a_
  • Heterogens: KX1, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3kx1A (A:)
apdsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvsen
dgcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegneka
lkravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwii
knswgenwgnkgyilmarnknnacgianlasfpkm

    Sequence, based on observed residues (ATOM records): (download) 
    >3kx1A (A:)
dsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvsendg
cgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegnekalk
ravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwiikn
swgenwgnkgyilmarnknnacgianlasfpkm