PDB entry 3kwn

View 3kwn on RCSB PDB site
Description: Cathepsin S in complex with Thioether Acetamide P3 inhibitor
Class: hydrolase
Keywords: glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen
Deposited on 2009-12-01, released 2010-04-14
Made obsolete by 5qc4 on 2017-12-20

The last revision prior to the SCOPe 2.08 freeze date was dated 2017-12-20, with a file datestamp of 2017-12-15.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: cathepsin S
  Species: Homo sapiens [TaxId:9606]
  Gene: CTSS
  Database cross-references and differences (RAF-indexed):
  • Uniprot P25774 (0-216)
    • engineered (24)
    • expression tag (217-218)
  Domains in SCOPe 2.08: d3kwna1, d3kwna2
• Chain 'B':
  Compound: cathepsin S
  Species: Homo sapiens [TaxId:9606]
  Gene: CTSS
  Database cross-references and differences (RAF-indexed):
  • Uniprot P25774 (0-216)
    • engineered (24)
    • expression tag (217-218)
  Domains in SCOPe 2.08: d3kwnb1, d3kwnb2
• Heterogens: 23Z, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3kwnA (A:)
  lpdsvdwrekgcvtevkyqgscgaswafsavgaleaqlklktgklvslsaqnlvdcstek
  ygnkgcnggfmttafqyiidnkgidsdasypykamdqkcqydskyraatcskytelpygr
  edvlkeavankgpvsvgvdarhpsfflyrsgvyyepsctqnvnhgvlvvgygdlngkeyw
  lvknswghnfgeegyirmarnkgnhcgiasfpsypeila
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3kwnB (B:)
  lpdsvdwrekgcvtevkyqgscgaswafsavgaleaqlklktgklvslsaqnlvdcstek
  ygnkgcnggfmttafqyiidnkgidsdasypykamdqkcqydskyraatcskytelpygr
  edvlkeavankgpvsvgvdarhpsfflyrsgvyyepsctqnvnhgvlvvgygdlngkeyw
  lvknswghnfgeegyirmarnkgnhcgiasfpsypeila