PDB entry 3kwb

View 3kwb on RCSB PDB site
Description: Structure of CatK covalently bound to a dioxo-triazine inhibitor
Class: hydrolase
Keywords: covalent bond, Cys 25, thioimidate, Disease mutation, Disulfide bond, Glycoprotein, Hydrolase, Lysosome, Protease, Thiol protease, Zymogen
Deposited on 2009-12-01, released 2010-04-07
The last revision prior to the SCOPe 2.07 freeze date was dated 2010-04-07, with a file datestamp of 2010-04-02.
Experiment type: XRAY
Resolution: 2.02 Å
R-factor: 0.202
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'X':
    Compound: cathepsin k
    Species: Homo sapiens [TaxId:9606]
    Gene: CTSK, CTSO, CTSO2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3kwbx_
  • Chain 'Y':
    Compound: cathepsin k
    Species: Homo sapiens [TaxId:9606]
    Gene: CTSK, CTSO, CTSO2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3kwby_
  • Heterogens: ORH, HOH

PDB Chain Sequences:

  • Chain 'X':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3kwbX (X:)
apdsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvsen
dgcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegneka
lkravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwii
knswgenwgnkgyilmarnknnacgianlasfpkm

  • Chain 'Y':
    Sequence, based on SEQRES records: (download) 
    >3kwbY (Y:)
apdsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvsen
dgcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegneka
lkravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwii
knswgenwgnkgyilmarnknnacgianlasfpkm

    Sequence, based on observed residues (ATOM records): (download) 
    >3kwbY (Y:)
dyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvsendgcgg
gymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegnekalkrav
arvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwiiknswg
enwgnkgyilmarnknnacgianlasfpkm