PDB entry 3kw4

View 3kw4 on RCSB PDB site
Description: Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug ticlopidine
Class: oxidoreductase
Keywords: P450, cytochrome P450 2B4, monooxygenase, oxidoreductase, membrane protein, CYP 2B4, CYP LM2, Endoplasmic reticulum, Heme, Iron, Membrane, Metal-binding, Microsome
Deposited on 2009-11-30, released 2010-09-15
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-08-31, with a file datestamp of 2011-08-26.
Experiment type: XRAY
Resolution: 2.67 Å
R-factor: 0.198
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome P450 2B4
    Species: Oryctolagus cuniculus [TaxId:9986]
    Gene: CYP2B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00178 (Start-471)
      • engineered (7)
      • engineered (9)
      • see remark 999 (201)
      • engineered (206)
      • expression tag (472)
    Domains in SCOPe 2.03: d3kw4a_
  • Heterogens: HEM, TIC, CM5, CH0, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3kw4A (A:)
makktsskgklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlc
gtdairealvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgk
rsveeriqeearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrll
dlffqsfslissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldps
nprdfidvyllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyph
vtervqkeieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrg
yvipkntevfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclge
giartelflffttilqnfsiaspvppedidltpresgvgnvppsyqirflarhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3kw4A (A:)
kgklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlcgtdaire
alvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgkrsveeri
qeearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrlldlffqsf
slissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldpsnprdfid
vyllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyphvtervqk
eieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrgyvipknt
evfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclgegiartel
flffttilqnfsiaspvppedidltpresgvgnvppsyqirflarh