PDB entry 3krx

View 3krx on RCSB PDB site
Description: Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal)
Class: protein binding
Keywords: RGS HOMOLOGY DOMAIN, ATP-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, Transducer, WD repeat, Cell membrane, Lipoprotein, Membrane, Methylation, Prenylation, PROTEIN BINDING
Deposited on 2009-11-19, released 2010-02-16
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-01-05, with a file datestamp of 2010-12-31.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.232
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ADRBK1, BARK, BARK1, GRK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3krxa1, d3krxa2, d3krxa3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Bos taurus [TaxId:9913]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3krxb_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3krxg_
  • Heterogens: BA1, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3krxA (A:)
adleavladvsylmamekskatpaaraskkillpepsirsvmqkyledrgevtfekifsq
klgyllfrdfclnhleearplvefyeeikkyekleteeervarsreifdsyimkellacs
hpfsksatehvqghlgkkqvppdlfqpyieeicqnlrgdvfqkfiesdkftrfcqwknve
lnihltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalneri
mlslvstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaaei
ilglehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymapev
lqkgvaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspel
rsllegllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaad
afdigsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrlearkk
aknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqsll
tmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrdayreaqqlvqrv
pkmknkprspvvelskvplvqrgsangl

    Sequence, based on observed residues (ATOM records): (download) 
    >3krxA (A:)
kkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyeei
kkyekleteeervarsreifdsyimkellahpfsksatehvqghlgkkqvppdlfqpyie
eicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcrka
dtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsfil
dlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehghv
risdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghspf
rqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevkesp
ffrsldwqmvflqkyppplippreedtkgiklldsdqelyrnfpltiserwqqevaetvf
dtinaetdrlearkkaknkqlgheedyalgkdcimhgymskmwqrryfylfpnrlewrge
geapqslltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrdayre
aqqlvqrvpkmknkprsp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3krxB (B:)
mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >3krxB (B:)
eldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamh
wgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnics
iynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftg
htgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafa
tgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalka
dragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3krxG (G:)
hhhhhhmasnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpv
pasenpfrekkffc

    Sequence, based on observed residues (ATOM records): (download) 
    >3krxG (G:)
siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrekkff
c