PDB entry 3krl

View 3krl on RCSB PDB site
Description: cFMS Tyrosine kinase in complex with 5-Cyano-furan-2-carboxylic acid [4-(4-methyl-piperazin-1-yl)-2-piperidin-1-yl-phenyl]-amide
Class: transferase/transferase inhibitor
Keywords: Kinase, inhibitor, chimera, ATP-binding, Disulfide bond, Glycoprotein, Immunoglobulin domain, Membrane, Nucleotide-binding, Phosphoprotein, Proto-oncogene, Receptor, Transferase, Transmembrane, Tyrosine-protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2009-11-18, released 2010-12-01
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-12-14, with a file datestamp of 2011-12-09.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.212
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Macrophage colony-stimulating factor 1 receptor, Basic fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF1R, FGFR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3krla_
  • Heterogens: KRL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3krlA (A:)
    gvdykykqkpkyqvrwkiiesyegnsytfidptqlpynekwefprnnlqfgktlgagafg
    kvveatafglgkedavlkvavkmlkstahadekealmselkimshlgqhenivnllgact
    hggpvlviteyccygdllnflrrkrppgleysynpshnpeeqlssrdllhfssqvaqgma
    flaskncihrdvaarnvlltnghvakigdfglardimndsnyivkgnarlpvkwmapesi
    fdcvytvqsdvwsygillweifslglnpypgilvnskfyklvkdgyqmaqpafapkniys
    imqacwalepthrptfqqicsflqeqaqedrrerd
    

    Sequence, based on observed residues (ATOM records): (download)
    >3krlA (A:)
    kyqvrwkiipynekwefprnnlqfgktlgagafgkvveatafglgkedavlkvavkmlks
    taadekealmselkimshlgqhenivnllgacthggpvlviteyccygdllnflrrkrql
    ssrdllhfssqvaqgmaflaskncihrdvaarnvlltnghvakigdfglardimndsnyi
    vkgarlpvkwmapesifdcvytvqsdvwsygillweifslglnpypgilvnskfyklvkd
    gyqmaqpafapkniysimqacwalepthrptfqqicsflqe