PDB entry 3kpr

View 3kpr on RCSB PDB site
Description: Crystal Structure of the LC13 TCR in complex with HLA B*4405 bound to EEYLKAWTF a mimotope
Class: immune system
Keywords: HLA B*4405, TCRpMHC structure, ternary complex, allorecognition, TCR recognition, self peptide, Disulfide bond, Glycoprotein, Host-virus interaction, Immune response, Membrane, MHC I, Polymorphism, IMMUNE SYSTEM
Deposited on 2009-11-16, released 2009-12-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, B-44 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-B, HLAB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30481 (0-275)
      • variant (115)
    Domains in SCOPe 2.08: d3kpra1, d3kpra2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3kprb_
  • Chain 'C':
    Compound: EEYLKAWTF, mimotope peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 3KPR (0-8)
  • Chain 'D':
    Compound: LC13 TCR alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3KPR (0-200)
    Domains in SCOPe 2.08: d3kprd1, d3kprd2
  • Chain 'E':
    Compound: LC13 TCR beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3KPR (0-240)
    Domains in SCOPe 2.08: d3kpre1, d3kpre2
  • Chain 'F':
    Compound: HLA class I histocompatibility antigen, B-44 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-B, HLAB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30481 (0-275)
      • variant (115)
    Domains in SCOPe 2.08: d3kprf1, d3kprf2
  • Chain 'G':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3kprg_
  • Chain 'H':
    Compound: EEYLKAWTF, mimotope peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 3KPR (0-8)
  • Chain 'I':
    Compound: LC13 TCR alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3KPR (0-200)
    Domains in SCOPe 2.08: d3kpri1, d3kpri2
  • Chain 'J':
    Compound: LC13 TCR beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3KPR (0-240)
    Domains in SCOPe 2.08: d3kprj1, d3kprj2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3kprA (A:)
gshsmryfytamsrpgrgeprfitvgyvddtlfvrfdsdatsprkeprapwieqegpeyw
dretqisktntqtyrenlrtalryynqseagshiiqrmygcdvgpdgrllrgydqyaydg
kdyialnedlsswtaadtaaqitqrkweaarvaeqdrayleglcveslrrylengketlq
radppkthvthhpisdhevtlrcwalgfypaeitltwqrdgedqtqdtelvetrpagdrt
fqkwaavvvpsgeeqrytchvqheglpkpltlrwep

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3kprB (B:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3kprD (D:)
kttqpnsmesneeepvhlpcnhstisgtdyihwyrqlpsqgpeyvihgltsnvnnrmasl
aiaedrksstlilhratlrdaavyycilplaggtsygkltfgqgtiltvhpniqnpdpav
yqlrdskssdksvclftdfdsqtnvsqskdsdvyitdktvldmrsmdfksnsavawsnks
dfacanafnnsiipedtffps

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3kprE (E:)
gvsqsprykvakrgqdvalrcdpisghvslfwyqqalgqgpefltyfqneaqldksglps
drffaerpegsvstlkiqrtqqedsavylcasslgqayeqyfgpgtrltvtedlknvfpp
evavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplkeqpal
ndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgra
d

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3kprF (F:)
gshsmryfytamsrpgrgeprfitvgyvddtlfvrfdsdatsprkeprapwieqegpeyw
dretqisktntqtyrenlrtalryynqseagshiiqrmygcdvgpdgrllrgydqyaydg
kdyialnedlsswtaadtaaqitqrkweaarvaeqdrayleglcveslrrylengketlq
radppkthvthhpisdhevtlrcwalgfypaeitltwqrdgedqtqdtelvetrpagdrt
fqkwaavvvpsgeeqrytchvqheglpkpltlrwep

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3kprG (G:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3kprI (I:)
kttqpnsmesneeepvhlpcnhstisgtdyihwyrqlpsqgpeyvihgltsnvnnrmasl
aiaedrksstlilhratlrdaavyycilplaggtsygkltfgqgtiltvhpniqnpdpav
yqlrdskssdksvclftdfdsqtnvsqskdsdvyitdktvldmrsmdfksnsavawsnks
dfacanafnnsiipedtffps

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3kprJ (J:)
gvsqsprykvakrgqdvalrcdpisghvslfwyqqalgqgpefltyfqneaqldksglps
drffaerpegsvstlkiqrtqqedsavylcasslgqayeqyfgpgtrltvtedlknvfpp
evavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplkeqpal
ndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgra
d