PDB entry 3kmc

View 3kmc on RCSB PDB site
Description: Crystal structure of catalytic domain of TACE with tartrate-based inhibitor
Class: hydrolase
Keywords: A disintegrin and metalloproteinase domain 17, TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, Cleavage on pair of basic residues, Glycoprotein, Membrane, Metal-binding, Metalloprotease, Notch signaling pathway, Phosphoprotein, Protease, Zymogen, HYDROLASE
Deposited on 2009-11-10, released 2009-12-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: TNF-alpha-converting enzyme
    Species: Homo sapiens [TaxId:9606]
    Gene: ADAM17, CSVP, TACE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P78536
      • engineered (51)
      • engineered (138)
      • engineered (237)
    Domains in SCOPe 2.08: d3kmca_
  • Chain 'B':
    Compound: TNF-alpha-converting enzyme
    Species: Homo sapiens [TaxId:9606]
    Gene: ADAM17, CSVP, TACE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P78536
      • engineered (51)
      • engineered (138)
      • engineered (237)
    Domains in SCOPe 2.08: d3kmcb_
  • Heterogens: ZN, INN, 403, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3kmcA (A:)
radpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkg
ygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcl
ahlftyqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygkti
ltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcs
kqsiyktieskaqecfqersnkgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3kmcA (A:)
pdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgygi
qieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclahl
ftyqdfdmgtlglayggspnshggvcpkayyspvgkkniylnsgltstknygktiltkea
dlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskqsiy
ktieskaqecfqers

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3kmcB (B:)
radpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkg
ygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcl
ahlftyqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygkti
ltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcs
kqsiyktieskaqecfqersnkgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3kmcB (B:)
pmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgygiqi
eqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclahlft
yqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygktiltkea
dlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskqsiy
ktieskaqecfqer