PDB entry 3kj0

View 3kj0 on RCSB PDB site
Description: Mcl-1 in complex with Bim BH3 mutant I2dY
Class: apoptosis
Keywords: bcl-2, bh3, apoptosis, protein-peptide complex, Alternative splicing, Cytoplasm, Developmental protein, Differentiation, Isopeptide bond, Membrane, Mitochondrion, Nucleus, Phosphoprotein, Polymorphism, Transmembrane, Ubl conjugation
Deposited on 2009-11-02, released 2010-02-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2010-03-23, with a file datestamp of 2010-03-19.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.187
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2L3, mcl-1, MCL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d3kj0a1, d3kj0a2
  • Chain 'B':
    Compound: Bcl-2-like protein 11
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2L11, BIM
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43521 (4-26)
      • expression tag (3)
      • engineered (9)
  • Heterogens: TRS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3kj0A (A:)
gsdelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafq
gmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciep
laesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg

    Sequence, based on observed residues (ATOM records): (download) 
    >3kj0A (A:)
gsdelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafq
gmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciep
laesitdvlvrtkrdwlvkqrgwdgfveffhvedleg

  • Chain 'B':
    No sequence available.