PDB entry 3khm
View 3khm on RCSB PDB site
Description: Crystal structure of sterol 14alpha-demethylase (CYP51) from Trypanosoma cruzi in complex with inhibitor fluconazole
Class: oxidoreductase
Keywords: sterol 14-alpha demethylase, cyp51, cytochrome p450, heme, oxidoreductase, monooxygenase, endoplasmic reticulum, transmembrane protein, sterol biosynthesis, lipids, membrane, iron, heme thiolate protein
Deposited on
2009-10-30, released
2009-11-10
The last revision prior to the SCOPe 2.06 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: 0.229
AEROSPACI score: 0.24
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Sterol 14 alpha-demethylase
Species: Trypanosoma cruzi [TaxId:5693]
Gene: cyp51
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d3khma_ - Heterogens: HEM, TPF
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3khmA (A:)
ktsgkgklppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdp
hehsrffsprneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfv
paiqhevrkfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllsk
messlipaavfmpwllrlplpqsarcrearaelqkilgeiivarekeeaskdnntsdllg
gllkavyrdgtrmslhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkei
defpaqlnydnvmdempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacs
pllshhdeeafpnprlwdperdekvdgafigfgagvhkcigqkfallqvktilatafrey
dfqllrdevpdpdyhtmvvgptlnqclvkytrkkklpshhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3khmA (A:)
ktsgkgklppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdp
hehsrffsprneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfv
paiqhevrkfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllsk
messlipallrlplpqsarcrearaelqkilgeiivareksdllggllkavyrdgtrmsl
hevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaqlnydnvmde
mpfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhdeeafpnpr
lwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrdevpdpdyh
tmvvgptlnqclvkytrkkkl