SCOPe 2.05: Structural Classification of Proteins

PDB entry 3kg2

View 3kg2 on RCSB PDB site
Description: AMPA subtype ionotropic glutamate receptor in complex with competitive antagonist ZK 200775
Class: membrane protein, transport protein
Keywords: ion channel, membrane protein, Cell membrane, Glycoprotein, Ion transport, Membrane, Postsynaptic cell membrane, Receptor, RNA editing, Synapse, Transmembrane, Transport, tetramer, transport protein
Deposited on 2009-10-28, released 2009-12-08
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-03-21, with a file datestamp of 2012-03-16.
Experiment type: XRAY
Resolution: 3.6 Å
R-factor: 0.287
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Glutamate receptor 2
Species: Rattus norvegicus [TaxId:10116]
Gene: Gria2, Glur2
Database cross-references and differences (RAF-indexed):
- Uniprot P19491 (0-End)
  - engineered (231)
  - engineered (375)
  - engineered (382)
  - engineered (400)
  - engineered (403-404)
  - engineered (406)
  - variant (734-735)
  - variant (744)
Domains in SCOPe 2.05: d3kg2a1, d3kg2a2, d3kg2a3
Chain 'B':
Compound: Glutamate receptor 2
Species: Rattus norvegicus [TaxId:10116]
Gene: Gria2, Glur2
Database cross-references and differences (RAF-indexed):
- Uniprot P19491 (0-End)
  - engineered (231)
  - engineered (375)
  - engineered (382)
  - engineered (400)
  - engineered (403-404)
  - engineered (406)
  - variant (734-735)
  - variant (744)
Domains in SCOPe 2.05: d3kg2b1, d3kg2b2, d3kg2b3
Chain 'C':
Compound: Glutamate receptor 2
Species: Rattus norvegicus [TaxId:10116]
Gene: Gria2, Glur2
Database cross-references and differences (RAF-indexed):
- Uniprot P19491 (0-End)
  - engineered (231)
  - engineered (375)
  - engineered (382)
  - engineered (400)
  - engineered (403-404)
  - engineered (406)
  - variant (734-735)
  - variant (744)
Domains in SCOPe 2.05: d3kg2c1, d3kg2c2, d3kg2c3
Chain 'D':
Compound: Glutamate receptor 2
Species: Rattus norvegicus [TaxId:10116]
Gene: Gria2, Glur2
Database cross-references and differences (RAF-indexed):
- Uniprot P19491 (0-End)
  - engineered (231)
  - engineered (375)
  - engineered (382)
  - engineered (400)
  - engineered (403-404)
  - engineered (406)
  - variant (734-735)
  - variant (744)
Domains in SCOPe 2.05: d3kg2d1, d3kg2d2, d3kg2d3
Heterogens: ZK1

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3kg2A (A:)
nsiqigglfprgadqeysafrvgmvqfstsefrltphidnlevansfavtnafcsqfsrg
vyaifgfydkksvntitsfcgtlhvsfitpsfptdgthpfviqmrpdlkgallslieyyq
wdkfaylydsdrglstlqavldsaaekkwqvtainvgninndkkdetyrslfqdlelkke
rrvildcerdkvndivdqvitigkhvkgyhyiianlgftdgdllkiqfggaevsgfqivd
yddslvskfierwstleekeypgahtatikytsaltydavqvmteafrnlrkqrieisrr
gnagdclanpavpwgqgveieralkqvqveglsgnikfdqngkrinytinimelktngpr
kigywsevdkmvlteddtsgleqktvvvttilespyvmmkanhaalagneryegycvdla
aeiakhcgfkykltivgdgkygardadtkiwngmvgelvygkadiaiapltitlvreevi
dfskpfmslgisimikkpqkskpgvfsfldplayeiwmcivfayigvsvvlflvsrfspy
ewhteefedgretqssestnefgifnslwfslgafmqqgadisprslsgrivggvwwfft
liiissytanlaafltvermvspiesaedlskqteiaygtldsgstkeffrrskiavfdk
mwtymrsaepsvfvrttaegvarvrkskgkyayllestmneyieqrkpcdtmkvggnlds
kgygiatpkgsslgtpvnlavlklseqglldklknkwwydkgecgakdsgskektsalsl
snvagvfyilvgglglamlvaliefcyksraeakrmkglvprg

Sequence, based on observed residues (ATOM records): (download)

>3kg2A (A:)
nsiqigglfprgadqeysafrvgmvqfstsefrltphidnlevansfavtnafcsqfsrg
vyaifgfydkksvntitsfcgtlhvsfitpsfptdgthpfviqmrpdlkgallslieyyq
wdkfaylydsdrglstlqavldsaaekkwqvtainvgninndkkdetyrslfqdlelkke
rrvildcerdkvndivdqvitigkhvkgyhyiianlgftdgdllkiqfggaevsgfqivd
yddslvskfierwstleekeypgahtatikytsaltydavqvmteafrnlrkqrieisrr
gnagdclanpavpwgqgveieralkqvqveglsgnikfdqngkrinytinimelktngpr
kigywsevdkmvlteddtsgleqktvvvttilespyvmmkanhaalagneryegycvdla
aeiakhcgfkykltivgdgkygardadtkiwngmvgelvygkadiaiapltitlvreevi
dfskpfmslgisimikkpqkskpgvfsfldplayeiwmcivfayigvsvvlflvstnefg
ifnslwfslgafmqprslsgrivggvwwfftliiissytanlaafltvermvspiesaed
lskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvrkskg
kyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgtpvnlavlklseqgl
ldklknkwwydkgecgakdsgskektsalslsnvagvfyilvgglglamlvaliefcyk

Chain 'B':
Sequence, based on SEQRES records: (download)

>3kg2B (B:)
nsiqigglfprgadqeysafrvgmvqfstsefrltphidnlevansfavtnafcsqfsrg
vyaifgfydkksvntitsfcgtlhvsfitpsfptdgthpfviqmrpdlkgallslieyyq
wdkfaylydsdrglstlqavldsaaekkwqvtainvgninndkkdetyrslfqdlelkke
rrvildcerdkvndivdqvitigkhvkgyhyiianlgftdgdllkiqfggaevsgfqivd
yddslvskfierwstleekeypgahtatikytsaltydavqvmteafrnlrkqrieisrr
gnagdclanpavpwgqgveieralkqvqveglsgnikfdqngkrinytinimelktngpr
kigywsevdkmvlteddtsgleqktvvvttilespyvmmkanhaalagneryegycvdla
aeiakhcgfkykltivgdgkygardadtkiwngmvgelvygkadiaiapltitlvreevi
dfskpfmslgisimikkpqkskpgvfsfldplayeiwmcivfayigvsvvlflvsrfspy
ewhteefedgretqssestnefgifnslwfslgafmqqgadisprslsgrivggvwwfft
liiissytanlaafltvermvspiesaedlskqteiaygtldsgstkeffrrskiavfdk
mwtymrsaepsvfvrttaegvarvrkskgkyayllestmneyieqrkpcdtmkvggnlds
kgygiatpkgsslgtpvnlavlklseqglldklknkwwydkgecgakdsgskektsalsl
snvagvfyilvgglglamlvaliefcyksraeakrmkglvprg

Sequence, based on observed residues (ATOM records): (download)

>3kg2B (B:)
nsiqigglfprgadqeysafrvgmvqfstsefrltphidnlevansfavtnafcsqfsrg
vyaifgfydkksvntitsfcgtlhvsfitpsfptdgthpfviqmrpdlkgallslieyyq
wdkfaylydsdrglstlqavldsaaekkwqvtainvgninndkkdetyrslfqdlelkke
rrvildcerdkvndivdqvitigkhvkgyhyiianlgftdgdllkiqfggaevsgfqivd
yddslvskfierwstleekeypgahtatikytsaltydavqvmteafrnlrkqrieisrr
gnagdclanpavpwgqgveieralkqvqveglsgnikfdqngkrinytinimelktngpr
kigywsevdkmvlteddtsgleqktvvvttilespyvmmkanhaalagneryegycvdla
aeiakhcgfkykltivgdgkygardadtkiwngmvgelvygkadiaiapltitlvreevi
dfskpfmslgisimikkpqkskpgvfsfldplayeiwmcivfayigvsvvlflvstnefg
ifnslwfslgafmqprslsgrivggvwwfftliiissytanlaafltvermvspiesaed
lskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvrkskg
kyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgtpvnlavlklseqgl
ldklknkwwydkgecgakdsgskektsalslsnvagvfyilvgglglamlvaliefcyk

Chain 'C':
Sequence, based on SEQRES records: (download)

>3kg2C (C:)
nsiqigglfprgadqeysafrvgmvqfstsefrltphidnlevansfavtnafcsqfsrg
vyaifgfydkksvntitsfcgtlhvsfitpsfptdgthpfviqmrpdlkgallslieyyq
wdkfaylydsdrglstlqavldsaaekkwqvtainvgninndkkdetyrslfqdlelkke
rrvildcerdkvndivdqvitigkhvkgyhyiianlgftdgdllkiqfggaevsgfqivd
yddslvskfierwstleekeypgahtatikytsaltydavqvmteafrnlrkqrieisrr
gnagdclanpavpwgqgveieralkqvqveglsgnikfdqngkrinytinimelktngpr
kigywsevdkmvlteddtsgleqktvvvttilespyvmmkanhaalagneryegycvdla
aeiakhcgfkykltivgdgkygardadtkiwngmvgelvygkadiaiapltitlvreevi
dfskpfmslgisimikkpqkskpgvfsfldplayeiwmcivfayigvsvvlflvsrfspy
ewhteefedgretqssestnefgifnslwfslgafmqqgadisprslsgrivggvwwfft
liiissytanlaafltvermvspiesaedlskqteiaygtldsgstkeffrrskiavfdk
mwtymrsaepsvfvrttaegvarvrkskgkyayllestmneyieqrkpcdtmkvggnlds
kgygiatpkgsslgtpvnlavlklseqglldklknkwwydkgecgakdsgskektsalsl
snvagvfyilvgglglamlvaliefcyksraeakrmkglvprg

Sequence, based on observed residues (ATOM records): (download)

>3kg2C (C:)
nsiqigglfprgadqeysafrvgmvqfstsefrltphidnlevansfavtnafcsqfsrg
vyaifgfydkksvntitsfcgtlhvsfitpsfptdgthpfviqmrpdlkgallslieyyq
wdkfaylydsdrglstlqavldsaaekkwqvtainvgninndkkdetyrslfqdlelkke
rrvildcerdkvndivdqvitigkhvkgyhyiianlgftdgdllkiqfggaevsgfqivd
yddslvskfierwstleekeypgahtatikytsaltydavqvmteafrnlrkqrieisrr
gnagdclanpavpwgqgveieralkqvqveglsgnikfdqngkrinytinimelktngpr
kigywsevdkmvlteddtsgleqktvvvttilespyvmmkanhaalagneryegycvdla
aeiakhcgfkykltivgdgkygardadtkiwngmvgelvygkadiaiapltitlvreevi
dfskpfmslgisimikkpqkskpgvfsfldplayeiwmcivfayigvsvvlflvstnefg
ifnslwfslgafmqprslsgrivggvwwfftliiissytanlaafltvermvspiesaed
lskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvrkskg
kyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgtpvnlavlklseqgl
ldklknkwwydkgecgakdsgskektsalslsnvagvfyilvgglglamlvaliefcyk

Chain 'D':
Sequence, based on SEQRES records: (download)

>3kg2D (D:)
nsiqigglfprgadqeysafrvgmvqfstsefrltphidnlevansfavtnafcsqfsrg
vyaifgfydkksvntitsfcgtlhvsfitpsfptdgthpfviqmrpdlkgallslieyyq
wdkfaylydsdrglstlqavldsaaekkwqvtainvgninndkkdetyrslfqdlelkke
rrvildcerdkvndivdqvitigkhvkgyhyiianlgftdgdllkiqfggaevsgfqivd
yddslvskfierwstleekeypgahtatikytsaltydavqvmteafrnlrkqrieisrr
gnagdclanpavpwgqgveieralkqvqveglsgnikfdqngkrinytinimelktngpr
kigywsevdkmvlteddtsgleqktvvvttilespyvmmkanhaalagneryegycvdla
aeiakhcgfkykltivgdgkygardadtkiwngmvgelvygkadiaiapltitlvreevi
dfskpfmslgisimikkpqkskpgvfsfldplayeiwmcivfayigvsvvlflvsrfspy
ewhteefedgretqssestnefgifnslwfslgafmqqgadisprslsgrivggvwwfft
liiissytanlaafltvermvspiesaedlskqteiaygtldsgstkeffrrskiavfdk
mwtymrsaepsvfvrttaegvarvrkskgkyayllestmneyieqrkpcdtmkvggnlds
kgygiatpkgsslgtpvnlavlklseqglldklknkwwydkgecgakdsgskektsalsl
snvagvfyilvgglglamlvaliefcyksraeakrmkglvprg

Sequence, based on observed residues (ATOM records): (download)

>3kg2D (D:)
nsiqigglfprgadqeysafrvgmvqfstsefrltphidnlevansfavtnafcsqfsrg
vyaifgfydkksvntitsfcgtlhvsfitpsfptdgthpfviqmrpdlkgallslieyyq
wdkfaylydsdrglstlqavldsaaekkwqvtainvgninndkkdetyrslfqdlelkke
rrvildcerdkvndivdqvitigkhvkgyhyiianlgftdgdllkiqfggaevsgfqivd
yddslvskfierwstleekeypgahtatikytsaltydavqvmteafrnlrkqrieisrr
gnagdclanpavpwgqgveieralkqvqveglsgnikfdqngkrinytinimelktngpr
kigywsevdkmvlteddtsgleqktvvvttilespyvmmkanhaalagneryegycvdla
aeiakhcgfkykltivgdgkygardadtkiwngmvgelvygkadiaiapltitlvreevi
dfskpfmslgisimikkpqkskpgvfsfldplayeiwmcivfayigvsvvlflvstnefg
ifnslwfslgafmqprslsgrivggvwwfftliiissytanlaafltvermvspiesaed
lskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvrkskg
kyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgtpvnlavlklseqgl
ldklknkwwydkgecgakdsgskektsalslsnvagvfyilvgglglamlvaliefcyk