PDB entry 3kfd

View 3kfd on RCSB PDB site
Description: Ternary complex of TGF-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Class: cytokine/cytokine receptor
Keywords: TGF-beta, TGF-b1, TGF-beta receptor type-1, TGF-beta receptor type-2, TbRII, TbRI, Growth factor, Receptor, Serine/threonine-protein kinase, CYTOKINE-CYTOKINE RECEPTOR complex
Deposited on 2009-10-27, released 2010-03-02
The last revision prior to the SCOPe 2.05 freeze date was dated 2010-05-19, with a file datestamp of 2010-05-14.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.22
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transforming growth factor beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB1, TGFB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3kfda_
  • Chain 'B':
    Compound: Transforming growth factor beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB1, TGFB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3kfdb_
  • Chain 'C':
    Compound: Transforming growth factor beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB1, TGFB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3kfdc_
  • Chain 'D':
    Compound: Transforming growth factor beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB1, TGFB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3kfdd_
  • Chain 'E':
    Compound: TGF-beta receptor type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFBR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3kfde_
  • Chain 'F':
    Compound: TGF-beta receptor type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFBR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3kfdf_
  • Chain 'G':
    Compound: TGF-beta receptor type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFBR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3kfdg_
  • Chain 'H':
    Compound: TGF-beta receptor type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFBR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3kfdh_
  • Chain 'I':
    Compound: TGF-beta receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFBR1
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: TGF-beta receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFBR1
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: TGF-beta receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFBR1
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: TGF-beta receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFBR1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3kfdA (A:)
aldtnycfssteknccvrqlyidfrkdlgwkwihepkgyhanfclgpcpyiwsldtqysk
vlalynqhnpgasaapccvpqaleplpivyyvgrkpkveqlsnmivrsckcs

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3kfdB (B:)
aldtnycfssteknccvrqlyidfrkdlgwkwihepkgyhanfclgpcpyiwsldtqysk
vlalynqhnpgasaapccvpqaleplpivyyvgrkpkveqlsnmivrsckcs

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3kfdC (C:)
aldtnycfssteknccvrqlyidfrkdlgwkwihepkgyhanfclgpcpyiwsldtqysk
vlalynqhnpgasaapccvpqaleplpivyyvgrkpkveqlsnmivrsckcs

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3kfdD (D:)
aldtnycfssteknccvrqlyidfrkdlgwkwihepkgyhanfclgpcpyiwsldtqysk
vlalynqhnpgasaapccvpqaleplpivyyvgrkpkveqlsnmivrsckcs

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3kfdE (E:)
vtdnngavkfpqlckfcdvrfstcdnqkscmsncsitsicekpqevcvavwrkndenitl
etvchdpklpyhdfiledaaspkcimkekkkpgetffmcscssdecndniifseey

    Sequence, based on observed residues (ATOM records): (download) 
    >3kfdE (E:)
avkfpqlckfcdvrfstcdnqkscmsncsitsicekpqevcvavwrkndenitletvchd
pklpyhdfiledaaspkcimkekkkpgetffmcscssdecndniifse

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3kfdF (F:)
vtdnngavkfpqlckfcdvrfstcdnqkscmsncsitsicekpqevcvavwrkndenitl
etvchdpklpyhdfiledaaspkcimkekkkpgetffmcscssdecndniifseey

    Sequence, based on observed residues (ATOM records): (download) 
    >3kfdF (F:)
avkfpqlckfcdvrfstcdnqkscmsncsitsicekpqevcvavwrkndenitletvchd
pklpyhdfiledaaspkcimkekkkpgetffmcscssdecndniif

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3kfdG (G:)
vtdnngavkfpqlckfcdvrfstcdnqkscmsncsitsicekpqevcvavwrkndenitl
etvchdpklpyhdfiledaaspkcimkekkkpgetffmcscssdecndniifseey

    Sequence, based on observed residues (ATOM records): (download) 
    >3kfdG (G:)
gavkfpqlckfcdvrfstcdnqkscmsncsitsicekpqevcvavwrkndenitletvch
dpklpyhdfiledaaspkcimkekkkpgetffmcscssdecndniifse

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >3kfdH (H:)
vtdnngavkfpqlckfcdvrfstcdnqkscmsncsitsicekpqevcvavwrkndenitl
etvchdpklpyhdfiledaaspkcimkekkkpgetffmcscssdecndniifseey

    Sequence, based on observed residues (ATOM records): (download) 
    >3kfdH (H:)
avkfpqlckfcdvrfstcdnqkscmsncsitsicekpqevcvavwrkndenitletvchd
pklpyhdfiledaaspkcimkekkkpgetffmcscssdecndniif

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    No sequence available.