PDB entry 3kc1

View 3kc1 on RCSB PDB site
Description: Crystal structure of human liver FBPase in complex with tricyclic inhibitor 19a
Class: hydrolase
Keywords: HYDROLASE, Allosteric enzyme, Carbohydrate metabolism, Disease mutation, Gluconeogenesis, Magnesium, Metal-binding, Polymorphism
Deposited on 2009-10-20, released 2010-02-02
The last revision prior to the SCOPe 2.01 freeze date was dated 2010-02-02, with a file datestamp of 2010-01-29.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.228
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3kc1a_
  • Chain 'B':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3kc1b_
  • Chain 'C':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3kc1c_
  • Chain 'D':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3kc1d_
  • Heterogens: 2T6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3kc1A (A:)
adqapfdtdvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygia
gstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpl
dgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcg
vncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapy
garyvgsmvadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgke
avldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >3kc1A (A:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagvkkldvl
sndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtif
giyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilv
dkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtl
vyggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapv
ilgspddvleflkvyekhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3kc1B (B:)
adqapfdtdvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygia
gstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpl
dgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcg
vncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapy
garyvgsmvadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgke
avldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >3kc1B (B:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagkkldvls
ndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifg
iyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvd
kdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlv
yggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvi
lgspddvleflkvyekhs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3kc1C (C:)
adqapfdtdvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygia
gstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpl
dgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcg
vncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapy
garyvgsmvadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgke
avldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >3kc1C (C:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagkkldvls
ndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifg
iyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvd
kdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlv
yggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvi
lgspddvleflkvyekhs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3kc1D (D:)
adqapfdtdvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygia
gstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpl
dgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcg
vncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapy
garyvgsmvadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgke
avldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >3kc1D (D:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagkldvlsn
dlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifgi
yrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvdk
dvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlvy
ggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvil
gspddvleflkvyekhs