PDB entry 3k8q

View 3k8q on RCSB PDB site
Description: Crystal structure of human purine nucleoside phosphorylase in complex with SerMe-Immucillin H
Class: transferase
Keywords: transition state analog inhibitor, hPNP, PNP, Immucillin H, SerMe-ImmH, Cytoskeleton, Disease mutation, Glycosyltransferase, TRANSFERASE
Deposited on 2009-10-14, released 2010-03-02
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-03-02, with a file datestamp of 2011-02-25.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.224
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: NP, PNP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (0-End)
      • engineered (50)
    Domains in SCOPe 2.01: d3k8qa_
  • Heterogens: 22A, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3k8qA (A:)
mengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprst
vpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaaggl
npkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwkq
mgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfsl
itnkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >3k8qA (A:)
mengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprst
vpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaaggl
npkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwkq
mgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfsl
itnkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplpd