PDB entry 3k7f

View 3k7f on RCSB PDB site
Description: Crystal Structure Analysis of a Phenhexyl/Oxazole/Carboxypyridine alpha-Ketoheterocycle Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase'
Class: hydrolase
Keywords: protein-inhibitor complex, FAAH, oxazole, Hydrolase, Membrane, Transmembrane
Deposited on 2009-10-13, released 2009-12-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-01-19, with a file datestamp of 2010-01-15.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.156
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fatty-acid amide hydrolase 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Faah, faah-1, Faah1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P97612
      • engineered (185)
      • engineered (187)
      • engineered (370)
      • engineered (428)
      • engineered (484)
      • engineered (488)
    Domains in SCOPe 2.08: d3k7fa_
  • Chain 'B':
    Compound: fatty-acid amide hydrolase 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Faah, faah-1, Faah1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P97612
      • engineered (185)
      • engineered (187)
      • engineered (370)
      • engineered (428)
      • engineered (484)
      • engineered (488)
    Domains in SCOPe 2.08: d3k7fb_
  • Heterogens: F2C, CL, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3k7fA (A:)
mgsshhhhhhssglvprgshmasrwtgrqkargaatrarqkqrasletmdkavqrfrlqn
pdldsealltlpllqlvqklqsgelspeavfftylgkawevnkgtncvtsyltdcetqls
qaprqgllygvpvslkecfsykghdstlglslnegmpsesdcvvvqvlklqgavpfvhtn
vpqsmfsydcsnplfgqtmnpwksskspggssggegaligsggsplglgtdiggsirfps
afcgicglkptgnrlsksglkgcvygqtavqlslgpmardveslalclkallcehlftld
ptvpplpfreevyrssrplrvgyyetdnytmpspamrralietkqrleaaghtlipflpn
nipyalevlstgglfsdggrsflqnfkgdfvdpclgdlililrlpswfkrllslllkplf
prlaaflnnmrprsaeklwklqheiemyrqsviaqwkamnldvlltpmlgpaldlntpgr
atgavsytmlyncldfpagvvpvttvtaeddaqmelykgyfgdiwdiilkkamknsvglp
vavqcvalpwqeelclrfmreveqlmtpqkqps

    Sequence, based on observed residues (ATOM records): (download) 
    >3k7fA (A:)
tgrqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgel
speavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghd
stlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkss
kspggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvy
gqtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyye
tdnytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqn
fkgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqhei
emyrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvtt
vtaeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveql
mtp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3k7fB (B:)
mgsshhhhhhssglvprgshmasrwtgrqkargaatrarqkqrasletmdkavqrfrlqn
pdldsealltlpllqlvqklqsgelspeavfftylgkawevnkgtncvtsyltdcetqls
qaprqgllygvpvslkecfsykghdstlglslnegmpsesdcvvvqvlklqgavpfvhtn
vpqsmfsydcsnplfgqtmnpwksskspggssggegaligsggsplglgtdiggsirfps
afcgicglkptgnrlsksglkgcvygqtavqlslgpmardveslalclkallcehlftld
ptvpplpfreevyrssrplrvgyyetdnytmpspamrralietkqrleaaghtlipflpn
nipyalevlstgglfsdggrsflqnfkgdfvdpclgdlililrlpswfkrllslllkplf
prlaaflnnmrprsaeklwklqheiemyrqsviaqwkamnldvlltpmlgpaldlntpgr
atgavsytmlyncldfpagvvpvttvtaeddaqmelykgyfgdiwdiilkkamknsvglp
vavqcvalpwqeelclrfmreveqlmtpqkqps

    Sequence, based on observed residues (ATOM records): (download) 
    >3k7fB (B:)
grqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgels
peavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghds
tlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkssk
spggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvyg
qtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyyet
dnytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqnf
kgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqheie
myrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvttv
taeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveqlm
tpqkq