PDB entry 3k74

View 3k74 on RCSB PDB site
Description: Disruption of protein dynamics by an allosteric effector antibody
Class: oxidoreductase
Keywords: Immunoglobulin, protein-nanobody complex, Antibiotic resistance, Methotrexate resistance, NADP, One-carbon metabolism, Oxidoreductase, Trimethoprim resistance
Deposited on 2009-10-12, released 2010-10-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Escherichia coli K-12 [TaxId:83333]
    Gene: b0048, DHFR, folA, JW0047, tmrA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3k74a_
  • Chain 'B':
    Compound: Nanobody
    Species: Lama glama [TaxId:9844]
    Gene: Lama
    Database cross-references and differences (RAF-indexed):
    • PDB 3K74 (0-114)
    Domains in SCOPe 2.07: d3k74b_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3k74A (A:)
    misliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
    ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
    gdthfpdyepddwesvfsefhdadaqnshsycfeilerr
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3k74B (B:)
    qlqesggglvqpggslrlscaasgftfnnywmywvrrapgkglewvsminpggiitkyae
    svkgrftisrdnakntlylqmnsltsedtavyycakdwatglakkgqgtqvtvss