PDB entry 3k2p

View 3k2p on RCSB PDB site
Description: HIV-1 Reverse Transcriptase Isolated RnaseH Domain with the Inhibitor beta-thujaplicinol Bound at the Active Site
Class: hydrolase
Keywords: RNAse H inhibitor, reverse transcriptase, AIDS, HIV, protein-inhibitor complex, structure-based drug design, tropolones, tropylium ion, divalent cation chelator, metal-binding, RNA-binding, hydrolase
Deposited on 2009-09-30, released 2010-02-09
The last revision prior to the SCOPe 2.06 freeze date was dated 2010-02-09, with a file datestamp of 2010-02-05.
Experiment type: XRAY
Resolution: 2.04 Å
R-factor: 0.227
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: reverse transcriptase
    Species: Human immunodeficiency virus type 1 [TaxId:11678]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3k2pa_
  • Chain 'B':
    Compound: reverse transcriptase
    Species: Human immunodeficiency virus type 1 [TaxId:11678]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3k2pb_
  • Heterogens: MN, JTH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3k2pA (A:)
alyqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelqaiyl
alqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgigg
neqvdklvsagirkil

    Sequence, based on observed residues (ATOM records): (download) 
    >3k2pA (A:)
yqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelqaiylal
qdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggne
qvdklvsagir

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3k2pB (B:)
alyqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelqaiyl
alqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgigg
neqvdklvsagirkil

    Sequence, based on observed residues (ATOM records): (download) 
    >3k2pB (B:)
yqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelqaiylal
qdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggne
qvdklvsagir