PDB entry 3k23

View 3k23 on RCSB PDB site
Description: Glucocorticoid Receptor with Bound D-prolinamide 11
Class: transcription
Keywords: Glucocorticoid Receptor, Steroid Hormone Receptor, Nuclear Receptor, GR, glucocorticoids, alpha helical sandwich, meta-channel, Alternative initiation, Chromatin regulator, Disease mutation, DNA-binding, Metal-binding, Nucleus, Pseudohermaphroditism, Receptor, Steroid-binding, Transcription, Transcription regulation, Zinc-finger, Activator
Deposited on 2009-09-29, released 2009-10-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glucocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: Grl, Nr3c1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04150
      • engineered (83)
      • engineered (119)
    Domains in SCOPe 2.08: d3k23a_
  • Chain 'B':
    Compound: Glucocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: Grl, Nr3c1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04150
      • engineered (83)
      • engineered (119)
    Domains in SCOPe 2.08: d3k23b_
  • Chain 'C':
    Compound: Glucocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: Grl, Nr3c1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04150
      • engineered (83)
      • engineered (119)
    Domains in SCOPe 2.08: d3k23c_
  • Chain 'D':
    Compound: nuclear receptor coactivator 2
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: nuclear receptor coactivator 2
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: nuclear receptor coactivator 2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: JZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3k23A (A:)
gsvpatlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwa
kaipgfrnlhlddqmtllqyswmylmafalgwrsyrqssanllcfapdliineqrmtlpg
mydqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelg
kaivkregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiit
nqipkysngnikkllfhqk

    Sequence, based on observed residues (ATOM records): (download) 
    >3k23A (A:)
lpqltptlvslleviepevlyagydsvpdstwrimttlnmlggrqviaavkwakaipgfr
nlhlddqmtllqyswmylmafalgwrsyrqssanllcfapdliineqgmydqckhmlyvs
selhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkregnssq
nwqrfyqltklldsmhevvenllnycfqtfldkmsiefpemlaeiitnqipkysngnikk
llfhq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3k23B (B:)
gsvpatlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwa
kaipgfrnlhlddqmtllqyswmylmafalgwrsyrqssanllcfapdliineqrmtlpg
mydqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelg
kaivkregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiit
nqipkysngnikkllfhqk

    Sequence, based on observed residues (ATOM records): (download) 
    >3k23B (B:)
qltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaipgfrn
lhlddqmtllqyswmylmafalgwrsyrqssanllcfapdliineqrmtlpgmydqckhm
lyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkres
qnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqipkysngni
kkllfhq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3k23C (C:)
gsvpatlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwa
kaipgfrnlhlddqmtllqyswmylmafalgwrsyrqssanllcfapdliineqrmtlpg
mydqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelg
kaivkregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiit
nqipkysngnikkllfhqk

    Sequence, based on observed residues (ATOM records): (download) 
    >3k23C (C:)
lpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaipgf
rnlhlddqmtllqyswmylmafalgwrsyrqssanllcfapdliineqrmtlpgmydqck
hmlyvsselhrlqvsyeeylcmktllllssvpkdglkqelfdeirmtyikelgkaivkre
gnssqnwqrfyqltklldsmhevvenllnycfqtfldktmiefpemlaeiitnqipkyni
kkllfh

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.