PDB entry 3jpv

View 3jpv on RCSB PDB site
Description: Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a pyrrolo[2,3-a]carbazole ligand
Class: transferase / transferase inhibitor
Keywords: oncogene, kinase, serine-threonine, PIM1, pyrrolo[2,3-a]carbazole, Structural Genomics Consortium, SGC, Alternative initiation, ATP-binding, Cell membrane, Manganese, Membrane, Metal-binding, Nucleotide-binding, Nucleus, Phosphoprotein, Proto-oncogene, Serine/threonine-protein kinase, Transferase, transferase - transferase inhibitor COMPLEX
Deposited on 2009-09-04, released 2009-10-27
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.176
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene serine/threonine-protein kinase Pim-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PIM1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11309
      • see remark 999 (250)
    Domains in SCOPe 2.05: d3jpva_
  • Chain 'B':
    Compound: Peptide (PIMTIDE) ARKRRRHPSGPPTA
    Species:
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 3JPV
  • Heterogens: 1DR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3jpvA (A:)
    smllskinslahlraapcndlhatklapgkekeplesqyqvgpllgsggfgsvysgirvs
    dnlpvaikhvekdrisdwgelpngtrvpmevvllkkvssgfsgvirlldwferpdsfvli
    lerpepvqdlfdfitergalqeelarsffwqvleavrhchncgvlhrdikdenilidlnr
    gelklidfgsgallkdtvytdfdgtrvysppewiryhryhgrsaavwslgillydmvcgd
    ipfehdeeiiggqvffrqrvssecqhlirwclalrpsdrptfeeiqnhpwmqdvllpqet
    aeihlhslspgps
    

    Sequence, based on observed residues (ATOM records): (download)
    >3jpvA (A:)
    plesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvl
    lkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvl
    eavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppew
    iryhryhgrsaavwslgillydmvcgdipfehdeeiiggqvffrqrvssecqhlirwcla
    lrpsdrptfeeiqnhpwmqdvllpqetaeihlh
    

  • Chain 'B':
    No sequence available.