PDB entry 3io7

View 3io7 on RCSB PDB site
Description: 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2
Class: transferase
Keywords: kinase, inhibitor, jak2, janus kinase, ATP-binding, Chromosomal rearrangement, Disease mutation, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Proto-oncogene, SH2 domain, Transferase, Tyrosine-protein kinase
Deposited on 2009-08-13, released 2009-11-10
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-11-17, with a file datestamp of 2009-11-13.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.206
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3io7a_
  • Heterogens: 1P5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3io7A (A:)
mgsshhhhhhssglvprgshnmtqfeerhlkflqqlgkgnfgsvemcrydplqdntgevv
avkklqhsteehlrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrd
ylqkhkeridhikllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltk
vlpqdkeyykvkepgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppa
efmrmigndkqgqmivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdl
alrvdqirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >3io7A (A:)
tqfeerhlkflqqlgkggsvemcrydplqdntgevvavkklqhsteehlrdfereieilk
slqhdnivkykgvcysrnlklimeylpygslrdylqkhkeridhikllqytsqickgmey
lgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyapesl
teskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellknng
rlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnm