PDB entry 3ii5
View 3ii5 on RCSB PDB site
Description: The Complex of wild-type B-RAF with Pyrazolo pyrimidine inhibitor
Class: transferase
Keywords: B-Raf, Kinase, protein-inhibitor complex, Acetylation, ATP-binding, Cardiomyopathy, Cytoplasm, Disease mutation, Metal-binding, Nucleotide-binding, Phorbol-ester binding, Phosphoprotein, Polymorphism, Proto-oncogene, Serine/threonine-protein kinase, Transferase, Zinc, Zinc-finger
Deposited on
2009-07-31, released
2009-11-10
The last revision prior to the SCOPe 2.05 freeze date was dated
2009-11-17, with a file datestamp of
2009-11-13.
Experiment type: XRAY
Resolution: 2.79 Å
R-factor: 0.209
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: B-Raf proto-oncogene serine/threonine-protein kinase
Species: Homo sapiens [TaxId:9606]
Gene: BRAF, BRAF1, RAFB1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3ii5a_ - Chain 'B':
Compound: B-Raf proto-oncogene serine/threonine-protein kinase
Species: Homo sapiens [TaxId:9606]
Gene: BRAF, BRAF1, RAFB1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3ii5b_ - Heterogens: 831, PO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3ii5A (A:)
mdrgshhhhhhsedrnrmktlgrrdssddweipdgqitvgqrigsgsfgtvykgkwhgdv
avkmlnvtaptpqqlqafknevgvlrktrhvnillfmgystkpqlaivtqwcegsslyhh
lhiietkfemiklidiarqtaqgmdylhaksiihrdlksnniflhedltvkigdfglatv
ksrwsgshqfeqlsgsilwmapevirmqdknpysfqsdvyafgivlyelmtgqlpysnin
nrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrderplfpqilasiellars
lpkihr
Sequence, based on observed residues (ATOM records): (download)
>3ii5A (A:)
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdyl
haksiihrdlksnniflhedltvkigdfglatvqlsgsilwmapevirmqdknpysfqsd
vyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclk
kkrderplfpqilasiellars
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3ii5B (B:)
mdrgshhhhhhsedrnrmktlgrrdssddweipdgqitvgqrigsgsfgtvykgkwhgdv
avkmlnvtaptpqqlqafknevgvlrktrhvnillfmgystkpqlaivtqwcegsslyhh
lhiietkfemiklidiarqtaqgmdylhaksiihrdlksnniflhedltvkigdfglatv
ksrwsgshqfeqlsgsilwmapevirmqdknpysfqsdvyafgivlyelmtgqlpysnin
nrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrderplfpqilasiellars
lpkihr
Sequence, based on observed residues (ATOM records): (download)
>3ii5B (B:)
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
aksiihrdlksnniflhedltvkigdfglagsilwmapevirmqdknpysfqsdvyafgi
vlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrder
plfpqilasiellarsl