PDB entry 3ibe

View 3ibe on RCSB PDB site
Description: Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma
Class: transferase
Keywords: PI3Kinase Inhibitor, ATP-binding, Kinase, Nucleotide-binding, Transferase
Deposited on 2009-07-15, released 2009-09-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P48736 (1-End)
      • expression tag (0)
      • variant (316)
    Domains in SCOPe 2.07: d3ibea1, d3ibea2, d3ibea3, d3ibea4, d3ibea5
  • Heterogens: SO4, L64, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ibeA (A:)
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdip
esqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee
wplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvf
veaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapals
skasaespsseskgkvrllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadkl
tsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatd
plnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsal
dvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfll
krglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqvieml
qkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekck
vmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldl
cllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfq
aaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginker
vpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpql
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhsa
hhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3ibeA (A:)
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmeqdfvlrvcg
rdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkeewlwdcdrkfrvkir
gidipvldltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgalln
lqiycgvrllyyvnlllidhrfllrrgeyvlhmwqissfnadkltsatnpdkensmsisi
lldnhpialpkhqptdrvraempnqlrkqleaiiatdplnpltaedkellwhfryeslkh
pkaypklfssvkwgqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiav
qklesledddvlhyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaq
srhyqqrfavileaylrgcgtamlhdftqqvqviemlqkvtldikslsaekydvssqvis
qlkqklenlqnsqlpesfrvpydpglkagalaiekckvmaskkkplwlefkcadptalsn
etigiifkhgddlrqdmlilqilrimesiwetesldlcllpygcistgdkigmieivkda
ttiakiqqstgafkdevlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhn
dnimitetgnlfhidfghkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalr
hhtnlliilfsmmlmtgmpltskedieyirdaltvgkneedakkyfldqievcrdkgwtv
qfnwflhlvl