PDB entry 3ia4

View 3ia4 on RCSB PDB site
Description: Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)
Class: oxidoreductase
Keywords: DHFR dihydrofolate reductase, NADPH, methotrexate, Oxidoreductase
Deposited on 2009-07-13, released 2009-07-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-09-29, with a file datestamp of 2009-09-25.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.157
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Moritella profunda [TaxId:111291]
    Gene: dyrA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3ia4a_
  • Chain 'B':
    Compound: dihydrofolate reductase
    Species: Moritella profunda [TaxId:111291]
    Gene: dyrA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3ia4b_
  • Chain 'C':
    Compound: dihydrofolate reductase
    Species: Moritella profunda [TaxId:111291]
    Gene: dyrA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3ia4c_
  • Chain 'D':
    Compound: dihydrofolate reductase
    Species: Moritella profunda [TaxId:111291]
    Gene: dyrA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3ia4d_
  • Heterogens: NDP, MTX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3ia4A (A:)
    mivsmiaalannrvigldnkmpwhlpaelqlfkratlgkpivmgrntfesigrplpgrln
    ivlsrqtdyqpegvtvvatledavvaagdveelmiiggatiynqclaaadrlylthielt
    tegdtwfpdyeqynwqeiehesyaaddknphnyrfsllervk
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ia4A (A:)
    mivsmiaalannrvigldnkmpwhlpaelqlfkratlgkpivmgrntfesigrplpgrln
    ivlsrqtdyqpegvtvvatledavvaagdveelmiiggatiynqclaaadrlylthielt
    tegdtwfpdyeqynwqeiehesyaaddknphnyrfsllerv
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3ia4B (B:)
    mivsmiaalannrvigldnkmpwhlpaelqlfkratlgkpivmgrntfesigrplpgrln
    ivlsrqtdyqpegvtvvatledavvaagdveelmiiggatiynqclaaadrlylthielt
    tegdtwfpdyeqynwqeiehesyaaddknphnyrfsllervk
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ia4B (B:)
    mivsmiaalannrvigldnkmpwhlpaelqlfkratlgkpivmgrntfesigrplpgrln
    ivlsrqtdyqpegvtvvatledavvaagdveelmiiggatiynqclaaadrlylthielt
    tegdtwfpdyeqynwqeiehesyaaddknphnyrfsllerv
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3ia4C (C:)
    mivsmiaalannrvigldnkmpwhlpaelqlfkratlgkpivmgrntfesigrplpgrln
    ivlsrqtdyqpegvtvvatledavvaagdveelmiiggatiynqclaaadrlylthielt
    tegdtwfpdyeqynwqeiehesyaaddknphnyrfsllervk
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ia4C (C:)
    mivsmiaalannrvigldnkmpwhlpaelqlfkratlgkpivmgrntfesigrplpgrln
    ivlsrqdyqpegvtvvatledavvaagdveelmiiggatiynqclaaadrlylthieltt
    egdtwfpdyeqynwqeiehesyaaddknphnyrfsllerv
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >3ia4D (D:)
    mivsmiaalannrvigldnkmpwhlpaelqlfkratlgkpivmgrntfesigrplpgrln
    ivlsrqtdyqpegvtvvatledavvaagdveelmiiggatiynqclaaadrlylthielt
    tegdtwfpdyeqynwqeiehesyaaddknphnyrfsllervk
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ia4D (D:)
    mivsmiaalannrvigldnkmpwhlpaelqlfkratlgkpivmgrntfesigrplpgrln
    ivlsrqtdyqpegvtvvatledavvaagdveelmiiggatiynqclaaadrlylthielt
    tegdtwfpdyeqynwqeiehesyaaddknphnyrfsllerv