PDB entry 3i8w
View 3i8w on RCSB PDB site
Description: Crystal structure of a metallacarborane inhibitor bound to HIV protease
Class: hydrolase/hydrolase inhibitor
Keywords: inhibitor, cobalt bis(1,2-dicarbollide), viral resistance, aspartic protease, AIDS, Aspartyl protease, Capsid maturation, Capsid protein, Cell membrane, DNA integration, DNA recombination, DNA-directed DNA polymerase, Endonuclease, Hydrolase, Lipoprotein, Magnesium, Membrane, Metal-binding, Multifunctional enzyme, Myristate, Nuclease, Nucleotidyltransferase, Nucleus, Phosphoprotein, Protease, RNA-binding, RNA-directed DNA polymerase, Transferase, Viral nucleoprotein, Virion, Zinc-finger, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Deposited on
2009-07-10, released
2009-12-01
The last revision prior to the SCOPe 2.08 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.178
AEROSPACI score: 0.56
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Protease
Species: Human immunodeficiency virus type 1 [TaxId:11686]
Gene: gag-pol
Database cross-references and differences (RAF-indexed):
- Uniprot P03367 (0-98)
- engineered (6)
- engineered (32)
- engineered (62)
Domains in SCOPe 2.08: d3i8wa_ - Heterogens: CB5, CL, GOL, HOH