PDB entry 3i68

View 3i68 on RCSB PDB site
Description: Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM2
Class: oxidoreductase
Keywords: Plasmodium falciparum, dihydroorotate dehydrogenase, triazolopyrimidine, inhibitor, DSM2,, FAD, Flavoprotein, Membrane, Mitochondrion, Mitochondrion inner membrane, Oxidoreductase, Pyrimidine biosynthesis, Transit peptide
Deposited on 2009-07-06, released 2009-07-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-10-20, with a file datestamp of 2009-10-16.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.214
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase homolog, mitochondrial
    Species: Plasmodium falciparum 3D7 [TaxId:36329]
    Gene: PFF0160c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3i68a_
  • Heterogens: J4Z, FMN, ORO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3i68A (A:)
mgsshhhhhhssglvprgshmasmtggqqgrdpfesynpefflydiflkfclkyidgeic
hdlflllgkynilpydtsndsiyactnikhldfinpfgvaagfdkngvcidsilklgfsf
ieigtitprgqtgnakprifrdvesrsiinscgfnnmgcdkvtenlilfrkrqeedklls
khivgvsigknkdtvnivddlkycinkigryadyiainvsspntpglrdnqeagklknii
lsvkeeidnleknnimndeflwfnttkkkplvfvklapdlnqeqkkeiadvlletnidgm
iisntttqindiksfenkkggvsgaklkdistkficemynytnkqipiiasggifsglda
lekieagasvcqlysclvfngmksavqikrelnhllyqrgyynlkeaigrkhsks

    Sequence, based on observed residues (ATOM records): (download) 
    >3i68A (A:)
esynpefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikhldfi
npfgvaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiinscgf
nnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigryady
iainvsspntpglrdnqeagklkniilsvkeeidnleknnimndeflwfnttkkkplvfv
klapdlnqeqkkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkf
icemynytnkqipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnh
llyqrgyynlkeaigrkh