PDB entry 3i54

View 3i54 on RCSB PDB site
Description: Crystal structure of MtbCRP in complex with cAMP
Class: DNA binding protein
Keywords: Mycobacterium tuberculosis, cAMP Receptor Protein, allosteric mechanism, DNA binding, inhibition, Structural Genomics, TB Structural Genomics Consortium, TBSGC, DNA-binding, Transcription, Transcription regulation, DNA BINDING PROTEIN
Deposited on 2009-07-03, released 2009-09-08
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.213
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: transcriptional regulator, Crp/Fnr family
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: MT3777, Rv3676
    Database cross-references and differences (RAF-indexed):
    • Uniprot O69644 (25-End)
      • expression tag (19-24)
    Domains in SCOPe 2.04: d3i54a1
  • Chain 'B':
    Compound: transcriptional regulator, Crp/Fnr family
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: MT3777, Rv3676
    Database cross-references and differences (RAF-indexed):
    • Uniprot O69644 (25-End)
      • expression tag (18-24)
    Domains in SCOPe 2.04: d3i54b1, d3i54b2
  • Chain 'C':
    Compound: transcriptional regulator, Crp/Fnr family
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: MT3777, Rv3676
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3i54c1, d3i54c2
  • Chain 'D':
    Compound: transcriptional regulator, Crp/Fnr family
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: MT3777, Rv3676
    Database cross-references and differences (RAF-indexed):
    • Uniprot O69644 (25-End)
      • expression tag (20-24)
    Domains in SCOPe 2.04: d3i54d1, d3i54d2
  • Heterogens: CMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3i54A (A:)
mgsshhhhhhssglggtenlyfqshmdeilaragifqgvepsaiaaltkqlqpvdfprgh
tvfaegepgdrlyiiisgkvkigrrapdgrenlltimgpsdmfgelsifdpgprtssatt
itevravsmdrdalrswiadrpeiseqllrvlarrlrrtnnnladliftdvpgrvakqll
qlaqrfgtqeggalrvthdltqeeiaqlvgasretvnkaladfahrgwirlegksvlisd
serlarrar

    Sequence, based on observed residues (ATOM records): (download) 
    >3i54A (A:)
lyfqshmdeilaragifqgvepsaiaaqpvdfprghtvfaegepgdrlyiiisgkvkigr
rapdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrpei
seqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltqee
iaqlvgasretvnkaladfahrgwirlegksvlisdserlarra

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3i54B (B:)
mgsshhhhhhssglggtenlyfqshmdeilaragifqgvepsaiaaltkqlqpvdfprgh
tvfaegepgdrlyiiisgkvkigrrapdgrenlltimgpsdmfgelsifdpgprtssatt
itevravsmdrdalrswiadrpeiseqllrvlarrlrrtnnnladliftdvpgrvakqll
qlaqrfgtqeggalrvthdltqeeiaqlvgasretvnkaladfahrgwirlegksvlisd
serlarrar

    Sequence, based on observed residues (ATOM records): (download) 
    >3i54B (B:)
nlyfqshmdeilaragifqepsaiaallqpvdfprghtvfaegepgdrlyiiisgkvkig
rrnlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrpeiseqll
rvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltqeeiaqlv
gasretvnkaladfahrgwirlegksvlisdserlarra

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3i54C (C:)
mgsshhhhhhssglggtenlyfqshmdeilaragifqgvepsaiaaltkqlqpvdfprgh
tvfaegepgdrlyiiisgkvkigrrapdgrenlltimgpsdmfgelsifdpgprtssatt
itevravsmdrdalrswiadrpeiseqllrvlarrlrrtnnnladliftdvpgrvakqll
qlaqrfgtqeggalrvthdltqeeiaqlvgasretvnkaladfahrgwirlegksvlisd
serlarrar

    Sequence, based on observed residues (ATOM records): (download) 
    >3i54C (C:)
aiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvkigrrapdgrenlltimgpsdm
fgelsifdpgprtssattitevravsmdrdalrswiadrpeiseqllrvlarrlrrtnnn
ladliftdvpgrvakqllqlaqrfgtqeggalrvthdltqeeiaqlvgasretvnkalad
fahrgwirlegksvlisdserlarra

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3i54D (D:)
mgsshhhhhhssglggtenlyfqshmdeilaragifqgvepsaiaaltkqlqpvdfprgh
tvfaegepgdrlyiiisgkvkigrrapdgrenlltimgpsdmfgelsifdpgprtssatt
itevravsmdrdalrswiadrpeiseqllrvlarrlrrtnnnladliftdvpgrvakqll
qlaqrfgtqeggalrvthdltqeeiaqlvgasretvnkaladfahrgwirlegksvlisd
serlarrar

    Sequence, based on observed residues (ATOM records): (download) 
    >3i54D (D:)
yfqshmdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkv
kigrrapdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiad
rpeiseqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdl
tqeeiaqlvgasretvnkaladfahrgwirlegksvlisdserlarra