PDB entry 3i3j

View 3i3j on RCSB PDB site
Description: Crystal Structure of the Bromodomain of Human EP300
Class: transferase
Keywords: Structural Genomics Bromodomain, P300, Consortium, SGC, Structural Genomics Consortium, Bromodomain, Cell cycle, Citrullination, Disease mutation, Host-virus interaction, Metal-binding, Methylation, Nucleus, Phosphoprotein, Transcription, Transcription regulation, Transferase, Zinc-finger
Deposited on 2009-06-30, released 2009-07-28
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-05-08, with a file datestamp of 2013-05-03.
Experiment type: XRAY
Resolution: 2.33 Å
R-factor: 0.231
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone acetyltransferase p300
    Species: Homo sapiens [TaxId:9606]
    Gene: EP300, P300
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3i3ja_
  • Chain 'B':
    Compound: Histone acetyltransferase p300
    Species: Homo sapiens [TaxId:9606]
    Gene: EP300, P300
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3i3jb_
  • Chain 'C':
    Compound: Histone acetyltransferase p300
    Species: Homo sapiens [TaxId:9606]
    Gene: EP300, P300
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3i3jc_
  • Chain 'D':
    Compound: Histone acetyltransferase p300
    Species: Homo sapiens [TaxId:9606]
    Gene: EP300, P300
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3i3jd_
  • Chain 'E':
    Compound: Histone acetyltransferase p300
    Species: Homo sapiens [TaxId:9606]
    Gene: EP300, P300
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3i3je_
  • Chain 'F':
    Compound: Histone acetyltransferase p300
    Species: Homo sapiens [TaxId:9606]
    Gene: EP300, P300
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3i3jf_
  • Chain 'G':
    Compound: Histone acetyltransferase p300
    Species: Homo sapiens [TaxId:9606]
    Gene: EP300, P300
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3i3jg_
  • Chain 'H':
    Compound: Histone acetyltransferase p300
    Species: Homo sapiens [TaxId:9606]
    Gene: EP300, P300
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3i3jh_
  • Chain 'I':
    Compound: Histone acetyltransferase p300
    Species: Homo sapiens [TaxId:9606]
    Gene: EP300, P300
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3i3ji_
  • Chain 'J':
    Compound: Histone acetyltransferase p300
    Species: Homo sapiens [TaxId:9606]
    Gene: EP300, P300
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3i3jj_
  • Chain 'K':
    Compound: Histone acetyltransferase p300
    Species: Homo sapiens [TaxId:9606]
    Gene: EP300, P300
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3i3jk_
  • Chain 'L':
    Compound: Histone acetyltransferase p300
    Species: Homo sapiens [TaxId:9606]
    Gene: EP300, P300
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3i3jl_
  • Heterogens: CL, PEG, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3i3jA (A:)
smapgqskkkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspm
dlstikrkldtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvm
qslg

    Sequence, based on observed residues (ATOM records): (download) 
    >3i3jA (A:)
kifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspmdlstikrkl
dtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvmqsl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3i3jB (B:)
smapgqskkkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspm
dlstikrkldtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvm
qslg

    Sequence, based on observed residues (ATOM records): (download) 
    >3i3jB (B:)
ifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspmdlstikrkld
tgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvmqslg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3i3jC (C:)
smapgqskkkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspm
dlstikrkldtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvm
qslg

    Sequence, based on observed residues (ATOM records): (download) 
    >3i3jC (C:)
kifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspmdlstikrkl
dtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvmqsl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3i3jD (D:)
smapgqskkkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspm
dlstikrkldtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvm
qslg

    Sequence, based on observed residues (ATOM records): (download) 
    >3i3jD (D:)
ifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspmdlstikrkld
tgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvmqsl

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3i3jE (E:)
smapgqskkkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspm
dlstikrkldtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvm
qslg

    Sequence, based on observed residues (ATOM records): (download) 
    >3i3jE (E:)
kifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspmdlstikrkl
dtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvmqslg

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3i3jF (F:)
smapgqskkkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspm
dlstikrkldtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvm
qslg

    Sequence, based on observed residues (ATOM records): (download) 
    >3i3jF (F:)
fkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspmdlstikrkldt
gqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvmqs

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3i3jG (G:)
smapgqskkkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspm
dlstikrkldtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvm
qslg

    Sequence, based on observed residues (ATOM records): (download) 
    >3i3jG (G:)
ifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspmdlstikrkld
tgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvmqsl

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >3i3jH (H:)
smapgqskkkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspm
dlstikrkldtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvm
qslg

    Sequence, based on observed residues (ATOM records): (download) 
    >3i3jH (H:)
ifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspmdlstikrkld
tgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvmqsl

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >3i3jI (I:)
smapgqskkkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspm
dlstikrkldtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvm
qslg

    Sequence, based on observed residues (ATOM records): (download) 
    >3i3jI (I:)
kifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspmdlstikrkl
dtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvmqslg

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >3i3jJ (J:)
smapgqskkkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspm
dlstikrkldtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvm
qslg

    Sequence, based on observed residues (ATOM records): (download) 
    >3i3jJ (J:)
ifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspmdlstikrkld
tgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvmqsl

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >3i3jK (K:)
smapgqskkkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspm
dlstikrkldtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvm
qslg

    Sequence, based on observed residues (ATOM records): (download) 
    >3i3jK (K:)
kifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspmdlstikrkl
dtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvmqsl

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >3i3jL (L:)
smapgqskkkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspm
dlstikrkldtgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvm
qslg

    Sequence, based on observed residues (ATOM records): (download) 
    >3i3jL (L:)
ifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivkspmdlstikrkld
tgqyqepwqyvddiwlmfnnawlynrktsrvykycsklsevfeqeidpvmqsl