PDB entry 3hxq
View 3hxq on RCSB PDB site
Description: Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding
Class: blood clotting/blood clotting regulator
Keywords: ARC1779, VWF, Platelet Glycoprotein Ib, Aptamer, ARC1772, Blood coagulation, Cell adhesion, Cleavage on pair of basic residues, Disease mutation, Disulfide bond, Extracellular matrix, Glycoprotein, Hemostasis, Isopeptide bond, Secreted, von Willebrand disease, BLOOD CLOTTING-BLOOD CLOTTING REGULATOR COMPLEX
Deposited on
2009-06-21, released
2009-11-17
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-22, with a file datestamp of
2017-11-17.
Experiment type: XRAY
Resolution: 2.69 Å
R-factor: N/A
AEROSPACI score: 0.17
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: von willebrand factor
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3hxqa_ - Chain 'B':
Compound: Aptamer ARC1172
Species: synthetic, synthetic
- Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3hxqA (A:)
edisepplhdfycsrlldlvflldgssrlseaefevlkafvvdmmerlrisqkwvrvavv
eyhdgshayiglkdrkrpselrriasqvkyagsqvastsevlkytlfqifskidrpeasr
ialllmasqepqrmsrnfvryvqglkkkkvivipvgigphanlkqirliekqapenkafv
lssvdeleqqrdeivsylcdlapeapppt
Sequence, based on observed residues (ATOM records): (download)
>3hxqA (A:)
pplhdfycsrlldlvflldgssrlseaefevlkafvvdmmerlrisqkwvrvavveyhdg
shayiglkdrkrpselrriasqvkyagsqvastsevlkytlfqifskidrpeasrialll
masqepqrmsrnfvryvqglkkkkvivipvgigphanlkqirliekqapenkafvlssvd
eleqqrdeivsylcdlapeap
- Chain 'B':
No sequence available.