PDB entry 3hxb

View 3hxb on RCSB PDB site
Description: Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 6)
Class: transferase
Keywords: protein prenylation inhibition, Metal-binding, Prenyltransferase, Transferase, Zinc
Deposited on 2009-06-20, released 2009-09-08
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-12-29, with a file datestamp of 2009-12-24.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.21
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Geranylgeranyl transferase type-2 subunit alpha
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Rabggta, Ggta
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08602 (Start-237)
      • linker (238-239)
    • Uniprot Q08602 (242-330)
  • Chain 'B':
    Compound: Geranylgeranyl transferase type-2 subunit beta
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Rabggtb, Ggtb
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3hxbb_
  • Heterogens: BD5, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3hxbB (B:)
mgtqqkdvtiksdapdtlllekhadyiasygskkddyeycmseylrmsgvywgltvmdlm
gqlhrmnkeeilvfikscqhecggvsasighdphllytlsavqiltlydsihvinvdkvv
ayvqslqkedgsfagdiwgeidtrfsfcavatlallgkldainvekaiefvlscmnfdgg
fgcrpgseshagqiycctgflaitsqlhqvnsdllgwwlcerqlpsgglngrpeklpdvc
yswwvlaslkiigrlhwidreklrsfilacqdeetggfadrpgdmvdpfhtlfgiaglsl
lgeeqikpvspvfcmpeevlqrvnvqpelvs

    Sequence, based on observed residues (ATOM records): (download) 
    >3hxbB (B:)
qkdvtiksdapdtlllekhadyiasygsdyeycmseylrmsgvywgltvmdlmgqlhrmn
keeilvfikscqhecggvsasighdphllytlsavqiltlydsihvinvdkvvayvqslq
kedgsfagdiwgeidtrfsfcavatlallgkldainvekaiefvlscmnfdggfgcrpgs
eshagqiycctgflaitsqlhqvnsdllgwwlcerqlpsgglngrpeklpdvcyswwvla
slkiigrlhwidreklrsfilacqdeetggfadrpgdmvdpfhtlfgiaglsllgeeqik
pvspvfcmpeevlqrvnvqpelvs