PDB entry 3hwz

View 3hwz on RCSB PDB site
Description: Structural Basis of the Prevention of NSAID-Induced Damage of the Gastrointestinal Tract by C-Terminal Half (C-lobe) of Bovine Colostrum Protein Lactoferrin: Binding and Structural Studies of the C-lobe Complexes with Indomethacin, Diclofenac, Aspirin and Ibuprofen
Class: Metal Binding Protein
Keywords: C-lobe, Drugs, Metal Binding Protein, Antibiotic, Antimicrobial, Disulfide bond, Glycoprotein, Hydrolase, Ion transport, Iron, Iron transport, Metal-binding, Phosphoprotein, Protease, Secreted, Serine protease, Transport
Deposited on 2009-06-19, released 2009-06-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-08-11, with a file datestamp of 2009-08-07.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.212
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lactotransferrin
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24627 (0-344)
      • conflict (223)
      • conflict (266)
    Domains in SCOPe 2.08: d3hwza_
  • Heterogens: ZN, FE, CO3, SO4, NAG, IMN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3hwzA (A:)
    ytrvvwcavgpeeqkkcqqwsqqsgqnvtcatasttddcivlvlkgeadalnldggyiyt
    agkcglvpvlaenrksskhssldcvlrptegylavavvkkanegltwnslkdkkschtav
    drtagwnipmglivnqtgscafdeffsqscapgadpksrlcalcagddqgldkcvpnske
    kyygytgafrclaedvgdvafvkndtvwentngestadwaknlkredfrllcldgtrkpv
    teaqschlavapnhavvsrsdraahveqvllhqqalfgkngkncpdkfclfksetknllf
    ndnteclaklggrptyeeylgteyvtaianlkkcstsplleacaf
    

    Sequence, based on observed residues (ATOM records): (download)
    >3hwzA (A:)
    ytrvvwcavgpeeqkkcqqwsqqsgqnvtcatasttddcivlvlkgeadalnldggyiyt
    agkcglvpvlaenrksskhssldcvlrptegylavavvkkanegltwnslkdkkschtav
    drtagwnipmglivnqtgscafdeffsqscapgadpksrlcalcagddqgldkcvpnske
    kyygytgafrclaedvgdvafvkndtvwentngestadwaknlkredfrllcldgtrkpv
    teaqschlavapnhavvsrsdraahveqvllhqqalfgkngkncpdkfclfksetknllf
    ndnteclaklggrptyeeylgteyvtaianlkkcsleacaf