PDB entry 3hwy
View 3hwy on RCSB PDB site
Description: Structural Basis of the Prevention of NSAID-Induced Damage of the Gastrointestinal Tract by C-Terminal Half (C-lobe) of Bovine Colostrum Protein Lactoferrin: Binding and Structural Studies of the C-lobe Complexes with Indomethacin, Diclofenac, Aspirin and Ibuprofen
Class: Metal Binding Protein
Keywords: C-lobe, Drugs, Metal Binding Protein, Antibiotic, Antimicrobial, Disulfide bond, Glycoprotein, Hydrolase, Ion transport, Iron, Iron transport, Metal-binding, Phosphoprotein, Protease, Secreted, Serine protease, Transport
Deposited on
2009-06-19, released
2009-06-30
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-08-11, with a file datestamp of
2009-08-07.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.183
AEROSPACI score: 0.43
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: lactotransferrin
Species: Bos taurus [TaxId:9913]
Database cross-references and differences (RAF-indexed):
- Uniprot P24627 (0-344)
- conflict (223)
- conflict (266)
Domains in SCOPe 2.08: d3hwya_ - Heterogens: AIN, SO4, ZN, FE, CO3, EOH, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3hwyA (A:)
ytrvvwcavgpeeqkkcqqwsqqsgqnvtcatasttddcivlvlkgeadalnldggyiyt
agkcglvpvlaenrksskhssldcvlrptegylavavvkkanegltwnslkdkkschtav
drtagwnipmglivnqtgscafdeffsqscapgadpksrlcalcagddqgldkcvpnske
kyygytgafrclaedvgdvafvkndtvwentngestadwaknlkredfrllcldgtrkpv
teaqschlavapnhavvsrsdraahveqvllhqqalfgkngkncpdkfclfksetknllf
ndnteclaklggrptyeeylgteyvtaianlkkcstsplleacaf
Sequence, based on observed residues (ATOM records): (download)
>3hwyA (A:)
ytrvvwcavgpeeqkkcqqwsqqsgqnvtcatasttddcivlvlkgeadalnldggyiyt
agkcglvpvlaenrksskhssldcvlrptegylavavvkkanegltwnslkdkkschtav
drtagwnipmglivnqtgscafdeffsqscapgadpksrlcalcagddqgldkcvpnske
kyygytgafrclaedvgdvafvkndtvwentngestadwaknlkredfrllcldgtrkpv
teaqschlavapnhavvsrsdraahveqvllhqqalfgkngkncpdkfclfksetknllf
ndnteclaklggrptyeeylgteyvtaianlkkcsleacaf