PDB entry 3hwv

View 3hwv on RCSB PDB site
Description: Structural Basis of the Prevention of NSAID-Induced Damage of the Gastrointestinal Tract by C-Terminal Half (C-lobe) of Bovine Colostrum Protein Lactoferrin: Binding and Structural Studies of the C-lobe Complexes with Indomethacin, Diclofenac, Aspirin and Ibuprofen
Class: metal-binding protein
Keywords: C-lobe, Drugs, METAL-BINDING PROTEIN, Antibiotic, Antimicrobial, Disulfide bond, Glycoprotein, Hydrolase, Ion transport, Iron, Iron transport, Metal-binding, Phosphoprotein, Protease, Secreted, Serine protease, Transport
Deposited on 2009-06-19, released 2009-06-30
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-08-11, with a file datestamp of 2009-08-07.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: 0.204
AEROSPACI score: 0.65 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lactotransferrin
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24627 (0-344)
      • conflict (223)
      • conflict (266)
    Domains in SCOPe 2.07: d3hwva_
  • Heterogens: FE, CO3, DIF, SO4, ZN, EOH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3hwvA (A:)
ytrvvwcavgpeeqkkcqqwsqqsgqnvtcatasttddcivlvlkgeadalnldggyiyt
agkcglvpvlaenrksskhssldcvlrptegylavavvkkanegltwnslkdkkschtav
drtagwnipmglivnqtgscafdeffsqscapgadpksrlcalcagddqgldkcvpnske
kyygytgafrclaedvgdvafvkndtvwentngestadwaknlkredfrllcldgtrkpv
teaqschlavapnhavvsrsdraahveqvllhqqalfgkngkncpdkfclfksetknllf
ndnteclaklggrptyeeylgteyvtaianlkkcstsplleacaf

    Sequence, based on observed residues (ATOM records): (download) 
    >3hwvA (A:)
ytrvvwcavgpeeqkkcqqwsqqsgqnvtcatasttddcivlvlkgeadalnldggyiyt
agkcglvpvlaenrksskhssldcvlrptegylavavvkkanegltwnslkdkkschtav
drtagwnipmglivnqtgscafdeffsqscapgadpksrlcalcagddqgldkcvpnske
kyygytgafrclaedvgdvafvkndtvwentngestadwaknlkredfrllcldgtrkpv
teaqschlavapnhavvsrsdraahveqvllhqqalfgkngkncpdkfclfksetknllf
ndnteclaklggrptyeeylgteyvtaianlkkcsleacaf