PDB entry 3hwd

View 3hwd on RCSB PDB site
Description: Crystal structure of Siderocalin (NGAL, Lipocalin 2) K125A-K134A mutant complexed with Ferric Enterobactin
Class: transport protein
Keywords: Lipocalin, siderophore, beta-barrel, Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid, Secreted, TRANSPORT PROTEIN
Deposited on 2009-06-17, released 2010-06-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-02-27, with a file datestamp of 2019-02-22.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neutrophil gelatinase-associated lipocalin
    Species: Homo sapiens [TaxId:9606]
    Gene: HNL, LCN2, NGAL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P80188 (Start-197)
      • engineered (106)
      • engineered (144)
      • engineered (153)
    Domains in SCOPe 2.08: d3hwda_
  • Chain 'B':
    Compound: Neutrophil gelatinase-associated lipocalin
    Species: Homo sapiens [TaxId:9606]
    Gene: HNL, LCN2, NGAL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P80188
      • engineered (106)
      • engineered (144)
      • engineered (153)
    Domains in SCOPe 2.08: d3hwdb_
  • Chain 'C':
    Compound: Neutrophil gelatinase-associated lipocalin
    Species: Homo sapiens [TaxId:9606]
    Gene: HNL, LCN2, NGAL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P80188
      • engineered (106)
      • engineered (144)
      • engineered (153)
    Domains in SCOPe 2.08: d3hwdc_
  • Heterogens: NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3hwdA (A:)
mplgllwlglallgalhaqaqdstsdlipapplskvplqqnfqdnqfqgkwyvvglagna
ilredkdpqkmyatiyelkedksynvtsvlfrkkkcdywirtfvpgsqpgeftlgniksy
pgltsylvrvvstnynqhamvffkavsqnreyfaitlygrtkeltselkenfirfskslg
lpenhivfpvpidqcidg

    Sequence, based on observed residues (ATOM records): (download) 
    >3hwdA (A:)
stsdlipapplskvplqqnfqdnqfqgkwyvvglagnailredkdpqkmyatiyelkedk
synvtsvlfrkkkcdywirtfvpgsqpgeftlgniksypgltsylvrvvstnynqhamvf
fkavsqnreyfaitlygrtkeltselkenfirfskslglpenhivfpvpidqcidg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3hwdB (B:)
mplgllwlglallgalhaqaqdstsdlipapplskvplqqnfqdnqfqgkwyvvglagna
ilredkdpqkmyatiyelkedksynvtsvlfrkkkcdywirtfvpgsqpgeftlgniksy
pgltsylvrvvstnynqhamvffkavsqnreyfaitlygrtkeltselkenfirfskslg
lpenhivfpvpidqcidg

    Sequence, based on observed residues (ATOM records): (download) 
    >3hwdB (B:)
sdlipapplskvplqqnfqdnqfqgkwyvvglagnailrepqkmyatiyelkedksynvt
svlfrkcdywirtfvpgsqpgeftlgniksypgltsylvrvvstnyhamvffkavsqnre
yfaitlygrtkeelkenfirfskslglpenhivfpvpidqcid

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3hwdC (C:)
mplgllwlglallgalhaqaqdstsdlipapplskvplqqnfqdnqfqgkwyvvglagna
ilredkdpqkmyatiyelkedksynvtsvlfrkkkcdywirtfvpgsqpgeftlgniksy
pgltsylvrvvstnynqhamvffkavsqnreyfaitlygrtkeltselkenfirfskslg
lpenhivfpvpidqcidg

    Sequence, based on observed residues (ATOM records): (download) 
    >3hwdC (C:)
sdlipapplskvplqqnfqdnqfqgkwyvvglagnailredkdpqkmyatiyelkedksy
nvtsvlfrkkkcdywirtfvpgsqpgeftlgniksypgltsylvrvvstnynqhamvffk
avsqnreyfaitlygrtkeltselkenfirfskslglpenhivfpvpidqcid