PDB entry 3hvo

View 3hvo on RCSB PDB site
Description: Structure of the genotype 2B HCV polymerase bound to a NNI
Class: transferase
Keywords: viral polymerase, ATP-binding, hydrolase, metal-binding, multifunctional enzyme, nucleotide-binding, nucleotidyltransferase, RNA replication, RNA-binding, RNA-directed RNA polymerase, TRANSFERASE
Deposited on 2009-06-16, released 2009-08-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-01-23, with a file datestamp of 2019-01-18.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Genome polyprotein
    Species: Hepatitis C virus isolate HC-J8 [TaxId:11115]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26661 (0-562)
      • engineered (4)
    Domains in SCOPe 2.08: d3hvoa_
  • Chain 'B':
    Compound: Genome polyprotein
    Species: Hepatitis C virus isolate HC-J8 [TaxId:11115]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26661 (0-562)
      • engineered (4)
    Domains in SCOPe 2.08: d3hvob_
  • Heterogens: VGI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3hvoA (A:)
smsytwtgalitpcgpeeeklpinplsnslmrfhnkvysttsrsaslrakkvtfdrvqvl
dahydsvlqdvkraaskvsarlltveeacaltpphsaksrygfgakevrslsrravnhir
svwedlledqhtpidttimaknevfcidptkggkkparlivypdlgvrvcekmalydiaq
klpkaimgpsygfqyspaervdfllkawgskkdpmgfsydtrcfdstvterdirteesiy
qacslpqeartvihslterlyvggpmtnskgqscgyrrcrasgvfttsmgntmtcyikal
aackaagivdpvmlvcgddlvvisesqgneedernlrafteamtrysappgdlprpeydl
elitscssnvsvaldsrgrrryfltrdpttpitraawetvrhspvnswlgniiqyaptiw
vrmvimthffsillaqdtlnqnlnfemygavysvnpldlpaiierlhgleafslhtysph
elsrvaatlrklgapplrawksraravrasliaqgaraaicgrylfnwavktklkltplp
easrldlsgwftvgagggdiyhs

    Sequence, based on observed residues (ATOM records): (download) 
    >3hvoA (A:)
smsytwtgalitpcgpeeeklpinplsnslmrfhnkvysttsrsaslrakkvtfdrvqvl
dahydsvlqdvkraaskvsarlltveeacaltpphsaksrygfgakevrslsrravnhir
svwedlledqhtpidttimaknevfcidpkkparlivypdlgvrvcekmalydiaqklpk
aimgpsygfqyspaervdfllkawgskkdpmgfsydtrcfdstvterdirteesiyqacs
lpqeartvihslterlyvggpmtnskgqscgyrrcrasgvfttsmgntmtcyikalaack
aagivdpvmlvcgddlvvisesqgneedernlrafteamtrysappgdlprpeydlelit
scssnvsvaldsrgrrryfltrdpttpitraawetvrhspvnswlgniiqyaptiwvrmv
imthffsillaqdtlnqnlnfemygavysvnpldlpaiierlhgleafslhtysphelsr
vaatlrklgapplrawksraravrasliaqgaraaicgrylfnwavktklkltplpeasr
ldlsgwftvgagggdiyhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3hvoB (B:)
smsytwtgalitpcgpeeeklpinplsnslmrfhnkvysttsrsaslrakkvtfdrvqvl
dahydsvlqdvkraaskvsarlltveeacaltpphsaksrygfgakevrslsrravnhir
svwedlledqhtpidttimaknevfcidptkggkkparlivypdlgvrvcekmalydiaq
klpkaimgpsygfqyspaervdfllkawgskkdpmgfsydtrcfdstvterdirteesiy
qacslpqeartvihslterlyvggpmtnskgqscgyrrcrasgvfttsmgntmtcyikal
aackaagivdpvmlvcgddlvvisesqgneedernlrafteamtrysappgdlprpeydl
elitscssnvsvaldsrgrrryfltrdpttpitraawetvrhspvnswlgniiqyaptiw
vrmvimthffsillaqdtlnqnlnfemygavysvnpldlpaiierlhgleafslhtysph
elsrvaatlrklgapplrawksraravrasliaqgaraaicgrylfnwavktklkltplp
easrldlsgwftvgagggdiyhs

    Sequence, based on observed residues (ATOM records): (download) 
    >3hvoB (B:)
smsytwtgalitpcgpeeeklpinplsnslmrfhnkvysttsrsaslrakkvtfdrvqvl
dahydsvlqdvkraaskvsarlltveeacaltpphsaksrygfgakevrslsrravnhir
svwedlledqhtpidttimaknevfcidkkparlivypdlgvrvcekmalydiaqklpka
imgpsygfqyspaervdfllkawgskkdpmgfsydtrcfdstvterdirteesiyqacsl
pqeartvihslterlyvggpmtnskgqscgyrrcrasgvfttsmgntmtcyikalaacka
agivdpvmlvcgddlvvisesqgneedernlrafteamtrysappgdlprpeydlelits
cssnvsvaldsrgrrryfltrdpttpitraawetvrhspvnswlgniiqyaptiwvrmvi
mthffsillaqdtlnqnlnfemygavysvnpldlpaiierlhgleafslhtysphelsrv
aatlrklgapplrawksraravrasliaqgaraaicgrylfnwavktklkltplpeasrl
dlsgwftvgagggdiyhs