PDB entry 3htc

View 3htc on RCSB PDB site
Description: the structure of a complex of recombinant hirudin and human alpha-thrombin
Class: hydrolase(serine protease)
Keywords: hydrolase(serine protease)
Deposited on 1993-06-11, released 1994-01-31
The last revision prior to the SCOP 1.73 freeze date was dated 2003-04-01, with a file datestamp of 2007-07-06.
Experiment type: -
Resolution: 2.3 Å
R-factor: 0.193
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: alpha-thrombin (large subunit)
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d3htc.1
  • Chain 'I':
    Compound: hirudin variant 2
    Species: Hirudinaria manillensis
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09945 (0-64)
      • conflict (46)
    Domains in SCOP 1.73: d3htci_
  • Chain 'L':
    Compound: alpha-thrombin (small subunit)
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d3htc.1

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >3htcH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >3htcH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqf

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3htcI (I:)
itytdctesgqnlclcegsnvcgkgnkcilgsngkgnqcvtgegtpkpeshnngdfeeip
eeylq

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >3htcL (L:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records): (download) 
    >3htcL (L:)
gsgeadcglrplfekksledkterellesyidgr