PDB entry 3hr1

View 3hr1 on RCSB PDB site
Description: Discovery of novel inhibitors of PDE10A
Class: hydrolase/hydrolase inhibitor
Keywords: Phosphodiesterase 10A, PDE 10A, PDE10 inhibitors, Allosteric enzyme, Alternative splicing, cAMP, cAMP-binding, cGMP, cGMP-binding, Cytoplasm, Hydrolase, Magnesium, Metal-binding, Nucleotide-binding, Zinc, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
Deposited on 2009-06-08, released 2009-08-04
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-09-22, with a file datestamp of 2009-09-18.
Experiment type: XRAY
Resolution: 1.53 Å
R-factor: 0.186
AEROSPACI score: 0.62 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Species: Rattus norvegicus [TaxId:10116]
    Gene: PDE10A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3hr1a_
  • Heterogens: SO4, PF9, ZN, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3hr1A (A:)
mhhhhhhssglvprgsammhhhhhhssglvprgsamgtseewqglmhfnlparicrdiel
fhfdigpfenmwpgifvymihrscgtscfeleklcrfimsvkknyrrvpyhnwkhavtva
hcmyailqnnnglftdlerkglliaclchdldhrgfsnsylqkfdhplaalyststmeqh
hfsqtvsilqleghnifstlssseyeqvleiirkaiiatdlalyfgnrkqleemyqtgsl
nlhnqshrdrviglmmtacdlcsvtklwpvtkltandiyaefwaegdemkklgiqpipmm
drdkrdevpqgqlgfynavaipcyttltqilpptepllkacrdnlnqwekvirgeetamw
isgpatskstsekptrkvdd

    Sequence, based on observed residues (ATOM records): (download) 
    >3hr1A (A:)
nlparicrdielfhfdigpfenmwpgifvymihrscgtscfeleklcrfimsvkknyrrv
pyhnwkhavtvahcmyailqnnnglftdlerkglliaclchdldhrgfsnsylqkfdhpl
aalyststmeqhhfsqtvsilqleghnifstlssseyeqvleiirkaiiatdlalyfgnr
kqleemyqtgslnlhnqshrdrviglmmtacdlcsvtklwpvtkltandiyaefwaegde
mkklgiqpipmmdrdkrdevpqgqlgfynavaipcyttltqilpptepllkacrdnlnqw
ekvir