PDB entry 3hpj

View 3hpj on RCSB PDB site
Description: Human Class I MHC HLA-A2 in complex with the WT-1 (126-134) peptide
Class: immune system
Keywords: WT-1, WT1, WT126 peptide, nonapeptide, MHC class I, HLA-A2, cancer vaccine, Disulfide bond, Glycoprotein, Host-virus interaction, Immune response, Membrane, MHC I, Phosphoprotein, Transmembrane, Disease mutation, Glycation, Immunoglobulin domain, Pyrrolidone carboxylic acid, Secreted, IMMUNE SYSTEM
Deposited on 2009-06-04, released 2010-06-23
The last revision prior to the SCOPe 2.03 freeze date was dated 2010-08-18, with a file datestamp of 2010-08-13.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.184
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: HLA class I histocompatibility antigen, A-2 alpha chain
  Species: Homo sapiens [TaxId:9606]
  Gene: HLA-A, HLAA
  Database cross-references and differences (RAF-indexed):
  • Uniprot P01892 (0-274)
• Chain 'B':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M, CDABP0092, HDCMA22P
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (1-99)
    • initiating methionine (0)
  Domains in SCOPe 2.03: d3hpjb_
• Chain 'C':
  Compound: WT126 peptide
  Species: human, synthetic [TaxId:9609]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P19544 (0-8)
• Chain 'D':
  Compound: HLA class I histocompatibility antigen, A-2 alpha chain
  Species: Homo sapiens [TaxId:9606]
  Gene: HLA-A, HLAA
  Database cross-references and differences (RAF-indexed):
  • Uniprot P01892 (0-274)
• Chain 'E':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M, CDABP0092, HDCMA22P
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (1-99)
    • initiating methionine (0)
  Domains in SCOPe 2.03: d3hpje_
• Chain 'F':
  Compound: WT126 peptide
  Species: human, synthetic [TaxId:9609]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P19544 (0-8)
• Heterogens: GOL, HOH

PDB Chain Sequences:

• Chain 'A':
  No sequence available.
  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3hpjB (B:)
  miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
  wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  No sequence available.
  
  
• Chain 'E':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3hpjE (E:)
  miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
  wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'F':
  No sequence available.