PDB entry 3hpg

View 3hpg on RCSB PDB site
Description: Visna virus integrase (residues 1-219) in complex with LEDGF IBD: examples of open integrase dimer-dimer interfaces
Deposited on 2009-06-04, released 2009-07-28
The last revision was dated 2009-08-04, with a file datestamp of 2009-07-31.
Experiment type: XRAY
Resolution: 3.28 Å
R-factor: 0.214
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: integrase
    Species: Maedi visna virus [TaxId:36374]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: integrase
    Species: Maedi visna virus [TaxId:36374]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: integrase
    Species: Maedi visna virus [TaxId:36374]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: integrase
    Species: Maedi visna virus [TaxId:36374]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35956 (2-End)
      • expression tag (1)
  • Chain 'E':
    Compound: integrase
    Species: Maedi visna virus [TaxId:36374]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35956 (2-End)
      • expression tag (1)
  • Chain 'F':
    Compound: integrase
    Species: Maedi visna virus [TaxId:36374]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35956 (2-End)
      • expression tag (1)
  • Chain 'G':
    Compound: PC4 and SFRS1-interacting protein
    Species: Homo sapiens [TaxId:9606]
    Gene: DFS70, LEDGF, PSIP1, PSIP2
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: PC4 and SFRS1-interacting protein
    Species: Homo sapiens [TaxId:9606]
    Gene: DFS70, LEDGF, PSIP1, PSIP2
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: PC4 and SFRS1-interacting protein
    Species: Homo sapiens [TaxId:9606]
    Gene: DFS70, LEDGF, PSIP1, PSIP2
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: PC4 and SFRS1-interacting protein
    Species: Homo sapiens [TaxId:9606]
    Gene: DFS70, LEDGF, PSIP1, PSIP2
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: PC4 and SFRS1-interacting protein
    Species: Homo sapiens [TaxId:9606]
    Gene: DFS70, LEDGF, PSIP1, PSIP2
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: PC4 and SFRS1-interacting protein
    Species: Homo sapiens [TaxId:9606]
    Gene: DFS70, LEDGF, PSIP1, PSIP2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3hpgA (A:)
mveniplaeeehnkwhqdavslhlefgiprtaaedivqqcdvcqenkmpstlrgsnkrgi
dhwqvdythyedkiilvwvetnsgliyaervkgetgqefrvqtmkwyamfapkslqsdng
pafvaestqllmkylgiehttgipwnpqsqalverthqtlkntleklipmfnafesalag
tlitlnikrkgglgtspmdififnkeqqriqqqskskqe

    Sequence, based on observed residues (ATOM records):
    >3hpgA (A:)
niplaeeehnkwhqdavslhlefgiprtaaedivqqcdvcqenkmgidhwqvdythyedk
iilvwvetnsgliyaervkgetgqefrvqtmkwyamfapkslqsdngpafvaestqllmk
ylgiehttpqsqalverthqtlkntleklipmfnafesalagtlitlnikrkgglgtspm
dififnkeqqriqq

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3hpgB (B:)
mveniplaeeehnkwhqdavslhlefgiprtaaedivqqcdvcqenkmpstlrgsnkrgi
dhwqvdythyedkiilvwvetnsgliyaervkgetgqefrvqtmkwyamfapkslqsdng
pafvaestqllmkylgiehttgipwnpqsqalverthqtlkntleklipmfnafesalag
tlitlnikrkgglgtspmdififnkeqqriqqqskskqe

    Sequence, based on observed residues (ATOM records):
    >3hpgB (B:)
niplaeeehnkwhqdavslhlefgiprtaaedivqqcdvcqenkmpstlrgsnkrgidhw
qvdythyedkiilvwvetnsgliyaervkgetgqefrvqtmkwyamfapkslqsdngpaf
vaestqllmkylgiehttgipwnpqsqalverthqtlkntleklipmfnafesalagtli
tlnikrkgglgtspmdififnkeqqriqq

  • Chain 'C':
    Sequence, based on SEQRES records:
    >3hpgC (C:)
mveniplaeeehnkwhqdavslhlefgiprtaaedivqqcdvcqenkmpstlrgsnkrgi
dhwqvdythyedkiilvwvetnsgliyaervkgetgqefrvqtmkwyamfapkslqsdng
pafvaestqllmkylgiehttgipwnpqsqalverthqtlkntleklipmfnafesalag
tlitlnikrkgglgtspmdififnkeqqriqqqskskqe

    Sequence, based on observed residues (ATOM records):
    >3hpgC (C:)
niplaeeehnkwhqdavslhlefgiprtaaedivqqcdvcqenkmidhwqvdythyedki
ilvwvetnsgliyaervkgetgqefrvqtmkwyamfapkslqsdngpafvaestqllmky
lgiehttgipwnpqsqalverthqtlkntleklipmfnafesalagtlitlnikrkgglg
tspmdififnkeqqriqq

  • Chain 'D':
    Sequence, based on SEQRES records:
    >3hpgD (D:)
mveniplaeeehnkwhqdavslhlefgiprtaaedivqqcdvcqenkmpstlrgsnkrgi
dhwqvdythyedkiilvwvetnsgliyaervkgetgqefrvqtmkwyamfapkslqsdng
pafvaestqllmkylgiehttgipwnpqsqalverthqtlkntleklipmfnafesalag
tlitlnikrkgglgtspmdififnkeqqriqqqskskqe

    Sequence, based on observed residues (ATOM records):
    >3hpgD (D:)
veniplaeeehnkwhqdavslhlefgiprtaaedivqqcdvcqenkmpdhwqvdythyed
kiilvwvetnsgliyaervkgetgqefrvqtmkwyamfapkslqsdngpafvaestqllm
kylgiehttnpqsqalverthqtlkntleklipmfnafesalagtlitlnikrkgglgts
pmdififnkeqqriqq

  • Chain 'E':
    Sequence, based on SEQRES records:
    >3hpgE (E:)
mveniplaeeehnkwhqdavslhlefgiprtaaedivqqcdvcqenkmpstlrgsnkrgi
dhwqvdythyedkiilvwvetnsgliyaervkgetgqefrvqtmkwyamfapkslqsdng
pafvaestqllmkylgiehttgipwnpqsqalverthqtlkntleklipmfnafesalag
tlitlnikrkgglgtspmdififnkeqqriqqqskskqe

    Sequence, based on observed residues (ATOM records):
    >3hpgE (E:)
veniplaeeehnkwhqdavslhlefgiprtaaedivqqcdvcqenkmpgidhwqvdythy
edkiilvwvetnsgliyaervkgetgqefrvqtmkwyamfapkslqsdngpafvaestql
lmkylgiehttalverthqtlkntleklipmfnafesalagtlitlnikrkgglgtspmd
ififnkeqqriqq

  • Chain 'F':
    Sequence, based on SEQRES records:
    >3hpgF (F:)
mveniplaeeehnkwhqdavslhlefgiprtaaedivqqcdvcqenkmpstlrgsnkrgi
dhwqvdythyedkiilvwvetnsgliyaervkgetgqefrvqtmkwyamfapkslqsdng
pafvaestqllmkylgiehttgipwnpqsqalverthqtlkntleklipmfnafesalag
tlitlnikrkgglgtspmdififnkeqqriqqqskskqe

    Sequence, based on observed residues (ATOM records):
    >3hpgF (F:)
veniplaeeehnkwhqdavslhlefgiprtaaedivqqcdvcqenkmprgidhwqvdyth
yedkiilvwvetnsgliyaervkgetgqefrvqtmkwyamfapkslqsdngpafvaestq
llmkylgiehttgipwnpqsqalverthqtlkntleklipmfnafesalagtlitlnikr
kgglgtspmdififnkeqqriqq

  • Chain 'G':
    Sequence, based on SEQRES records:
    >3hpgG (G:)
smdsrlqrihaeiknslkidnldvnrciealdelaslqvtmqqaqkhtemittlkkirrf
kvsqvimekstmlynkfknmflvgegdsvlevlfq

    Sequence, based on observed residues (ATOM records):
    >3hpgG (G:)
mdsrlqrihaeiknslkidnldvnrciealdelqvtmqqaqkhtemittlkkirrfkvsq
vimekstmlynkf

  • Chain 'H':
    Sequence, based on SEQRES records:
    >3hpgH (H:)
smdsrlqrihaeiknslkidnldvnrciealdelaslqvtmqqaqkhtemittlkkirrf
kvsqvimekstmlynkfknmflvgegdsvlevlfq

    Sequence, based on observed residues (ATOM records):
    >3hpgH (H:)
smdsrlqrihaeiknslkidnldvnrciealdelvtmqqaqkhtemittlkkirrfkvsq
vimekstm

  • Chain 'I':
    Sequence, based on SEQRES records:
    >3hpgI (I:)
smdsrlqrihaeiknslkidnldvnrciealdelaslqvtmqqaqkhtemittlkkirrf
kvsqvimekstmlynkfknmflvgegdsvlevlfq

    Sequence, based on observed residues (ATOM records):
    >3hpgI (I:)
mdsrlqrihaeiknslkidnldvnrciealdelastmqqaqkhtemittlkkirrfkvsq
vimekstm

  • Chain 'J':
    Sequence, based on SEQRES records:
    >3hpgJ (J:)
smdsrlqrihaeiknslkidnldvnrciealdelaslqvtmqqaqkhtemittlkkirrf
kvsqvimekstmlynkfknmflvgegdsvlevlfq

    Sequence, based on observed residues (ATOM records):
    >3hpgJ (J:)
smdsrlqrihaeiknslkidnldvnrciealdelaslqvtmqqaqkhtemittlkkirrf
kvsqvimekstmlynkf

  • Chain 'K':
    Sequence, based on SEQRES records:
    >3hpgK (K:)
smdsrlqrihaeiknslkidnldvnrciealdelaslqvtmqqaqkhtemittlkkirrf
kvsqvimekstmlynkfknmflvgegdsvlevlfq

    Sequence, based on observed residues (ATOM records):
    >3hpgK (K:)
smdsrlqrihaeiknslkidnldvnrciealdelaemittlkkirrfkvsqvimekstml
ynkfknm

  • Chain 'L':
    Sequence, based on SEQRES records:
    >3hpgL (L:)
smdsrlqrihaeiknslkidnldvnrciealdelaslqvtmqqaqkhtemittlkkirrf
kvsqvimekstmlynkfknmflvgegdsvlevlfq

    Sequence, based on observed residues (ATOM records):
    >3hpgL (L:)
mdsrlqrihaeiknslkidnldvnrciealdevtmqqaqkhtemittlkkirrfkvsqvi
m