PDB entry 3hp5
View 3hp5 on RCSB PDB site
Description: Crystal Structure of Human p38alpha complexed with a pyrimidopyridazinone compound
Class: Transferase
Keywords: two lobes, three ligands, three binding sites, distal and extra sites. peptide flip, ATP-binding, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Deposited on
2009-06-03, released
2009-09-29
The last revision prior to the SCOPe 2.05 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.217
AEROSPACI score: 0.34
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Mitogen-activated protein kinase 14
Species: Homo sapiens [TaxId:9606]
Gene: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, THP-1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3hp5a_ - Heterogens: 52P, I46, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3hp5A (A:)
msqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfq
siihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcq
kltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemt
gyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvg
tpgaellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaa
qalahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppldqeemes
Sequence, based on observed residues (ATOM records): (download)
>3hp5A (A:)
ptfyrqelnktiwevperyqnlspvgsvcaafdtktglrvavkklsrpfqsiihakrtyr
elrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfl
iyqilrglkyihsadiihrdlkpsnlavnedcelkildfgvatrwyrapeimlnwmhynq
tvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkissesarnyiqsl
tqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhdpddepvadp
ydqsfesrdllidewksltydevisfvppp