PDB entry 3hn3

View 3hn3 on RCSB PDB site
Description: Human beta-glucuronidase at 1.7 A resolution
Class: hydrolase
Keywords: LYSOSOMAL ENZYME, ACID HYDROLASE, GLYCOSIDASE, Disease mutation, Glycoprotein, Hydrolase, Lysosome, Mucopolysaccharidosis
Deposited on 2009-05-29, released 2009-12-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-04, with a file datestamp of 2017-09-29.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: beta-glucuronidase
    Species: Homo sapiens [TaxId:9606]
    Gene: PLACENTAL GUS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3hn3a1, d3hn3a2, d3hn3a3
  • Chain 'B':
    Compound: beta-glucuronidase
    Species: Homo sapiens [TaxId:9606]
    Gene: PLACENTAL GUS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3hn3b1, d3hn3b2, d3hn3b3
  • Chain 'D':
    Compound: beta-glucuronidase
    Species: Homo sapiens [TaxId:9606]
    Gene: PLACENTAL GUS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3hn3d1, d3hn3d2, d3hn3d3
  • Chain 'E':
    Compound: beta-glucuronidase
    Species: Homo sapiens [TaxId:9606]
    Gene: PLACENTAL GUS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3hn3e1, d3hn3e2, d3hn3e3
  • Heterogens: NDG, NAG, BMA, MAN, GUP, MRD, MPD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3hn3A (A:)
lglqggmlypqespsreckeldglwsfradfsdnrrrgfeeqwyrrplwesgptvdmpvp
ssfndisqdwrlrhfvgwvwyerevilperwtqdlrtrvvlrigsahsyaivwvngvdtl
eheggylpfeadisnlvqvgplpsrlritiainntltpttlppgtiqyltdtskypkgyf
vqntyfdffnyaglqrsvllyttpttyidditvttsveqdsglvnyqisvkgsnlfklev
rlldaenkvvangtgtqgqlkvpgvslwwpylmherpaylyslevqltaqtslgpvsdfy
tlpvgirtvavtksqflingkpfyfhgvnkhedadirgkgfdwpllvkdfnllrwlgana
frtshypyaeevmqmcdrygivvidecpgvglalpqffnnvslhhhmqvmeevvrrdknh
pavvmwsvanepashlesagyylkmviahtksldpsrpvtfvsnsnyaadkgapyvdvic
lnsyyswyhdyghleliqlqlatqfenwykkyqkpiiqseygaetiagfhqdpplmftee
yqkslleqyhlgldqkrrkyvvgeliwnfadfmteqsptrvlgnkkgiftrqrqpksaaf
llrerywkianet

    Sequence, based on observed residues (ATOM records): (download) 
    >3hn3A (A:)
glqggmlypqespsreckeldglwsfradfsdnrrrgfeeqwyrrplwesgptvdmpvps
sfndisqdwrlrhfvgwvwyerevilperwtqdlrtrvvlrigsahsyaivwvngvdtle
heggylpfeadisnlvqvgsrlritiainntltpttlppgtiqyltdtskypkgyfvqnt
yfdffnyaglqrsvllyttpttyidditvttsveqdsglvnyqisvkgsnlfklevrlld
aenkvvangtgtqgqlkvpgvslwwpylmherpaylyslevqltaqtslgpvsdfytlpv
girtvavtksqflingkpfyfhgvnkhedadirgkgfdwpllvkdfnllrwlganafrts
hypyaeevmqmcdrygivvidecpgvglalpqffnnvslhhhmqvmeevvrrdknhpavv
mwsvanepashlesagyylkmviahtksldpsrpvtfvsnsnyaadkgapyvdviclnsy
yswyhdyghleliqlqlatqfenwykkyqkpiiqseygaetiagfhqdpplmfteeyqks
lleqyhlgldqkrrkyvvgeliwnfadfmteqsptrvlgnkkgiftrqrqpksaafllre
rywkiane

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3hn3B (B:)
lglqggmlypqespsreckeldglwsfradfsdnrrrgfeeqwyrrplwesgptvdmpvp
ssfndisqdwrlrhfvgwvwyerevilperwtqdlrtrvvlrigsahsyaivwvngvdtl
eheggylpfeadisnlvqvgplpsrlritiainntltpttlppgtiqyltdtskypkgyf
vqntyfdffnyaglqrsvllyttpttyidditvttsveqdsglvnyqisvkgsnlfklev
rlldaenkvvangtgtqgqlkvpgvslwwpylmherpaylyslevqltaqtslgpvsdfy
tlpvgirtvavtksqflingkpfyfhgvnkhedadirgkgfdwpllvkdfnllrwlgana
frtshypyaeevmqmcdrygivvidecpgvglalpqffnnvslhhhmqvmeevvrrdknh
pavvmwsvanepashlesagyylkmviahtksldpsrpvtfvsnsnyaadkgapyvdvic
lnsyyswyhdyghleliqlqlatqfenwykkyqkpiiqseygaetiagfhqdpplmftee
yqkslleqyhlgldqkrrkyvvgeliwnfadfmteqsptrvlgnkkgiftrqrqpksaaf
llrerywkianet

    Sequence, based on observed residues (ATOM records): (download) 
    >3hn3B (B:)
glqggmlypqespsreckeldglwsfradfsdnrrrgfeeqwyrrplwesgptvdmpvps
sfndisqdwrlrhfvgwvwyerevilperwtqdlrtrvvlrigsahsyaivwvngvdtle
heggylpfeadisnlvqvgsrlritiainntltpttlppgtiqyltdtskypkgyfvqnt
yfdffnyaglqrsvllyttpttyidditvttsveqdsglvnyqisvkgsnlfklevrlld
aenkvvangtgtqgqlkvpgvslwwpylmherpaylyslevqltaqtslgpvsdfytlpv
girtvavtksqflingkpfyfhgvnkhedadirgkgfdwpllvkdfnllrwlganafrts
hypyaeevmqmcdrygivvidecpgvglalpqffnnvslhhhmqvmeevvrrdknhpavv
mwsvanepashlesagyylkmviahtksldpsrpvtfvsnsnyaadkgapyvdviclnsy
yswyhdyghleliqlqlatqfenwykkyqkpiiqseygaetiagfhqdpplmfteeyqks
lleqyhlgldqkrrkyvvgeliwnfadfmteqsptrvlgnkkgiftrqrqpksaafllre
rywkianet

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3hn3D (D:)
lglqggmlypqespsreckeldglwsfradfsdnrrrgfeeqwyrrplwesgptvdmpvp
ssfndisqdwrlrhfvgwvwyerevilperwtqdlrtrvvlrigsahsyaivwvngvdtl
eheggylpfeadisnlvqvgplpsrlritiainntltpttlppgtiqyltdtskypkgyf
vqntyfdffnyaglqrsvllyttpttyidditvttsveqdsglvnyqisvkgsnlfklev
rlldaenkvvangtgtqgqlkvpgvslwwpylmherpaylyslevqltaqtslgpvsdfy
tlpvgirtvavtksqflingkpfyfhgvnkhedadirgkgfdwpllvkdfnllrwlgana
frtshypyaeevmqmcdrygivvidecpgvglalpqffnnvslhhhmqvmeevvrrdknh
pavvmwsvanepashlesagyylkmviahtksldpsrpvtfvsnsnyaadkgapyvdvic
lnsyyswyhdyghleliqlqlatqfenwykkyqkpiiqseygaetiagfhqdpplmftee
yqkslleqyhlgldqkrrkyvvgeliwnfadfmteqsptrvlgnkkgiftrqrqpksaaf
llrerywkianet

    Sequence, based on observed residues (ATOM records): (download) 
    >3hn3D (D:)
lqggmlypqespsreckeldglwsfradfsdnrrrgfeeqwyrrplwesgptvdmpvpss
fndisqdwrlrhfvgwvwyerevilperwtqdlrtrvvlrigsahsyaivwvngvdtleh
eggylpfeadisnlvqvsrlritiainntltpttlppgtiqyltdtskypkgyfvqntyf
dffnyaglqrsvllyttpttyidditvttsveqdsglvnyqisvkgsnlfklevrlldae
nkvvangtgtqgqlkvpgvslwwpylmherpaylyslevqltaqtslgpvsdfytlpvgi
rtvavtksqflingkpfyfhgvnkhedadirgkgfdwpllvkdfnllrwlganafrtshy
pyaeevmqmcdrygivvidecpgvglalpqffnnvslhhhmqvmeevvrrdknhpavvmw
svanepashlesagyylkmviahtksldpsrpvtfvsnsnyaadkgapyvdviclnsyys
wyhdyghleliqlqlatqfenwykkyqkpiiqseygaetiagfhqdpplmfteeyqksll
eqyhlgldqkrrkyvvgeliwnfadfmteqsptrvlgnkkgiftrqrqpksaafllrery
wkianet

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3hn3E (E:)
lglqggmlypqespsreckeldglwsfradfsdnrrrgfeeqwyrrplwesgptvdmpvp
ssfndisqdwrlrhfvgwvwyerevilperwtqdlrtrvvlrigsahsyaivwvngvdtl
eheggylpfeadisnlvqvgplpsrlritiainntltpttlppgtiqyltdtskypkgyf
vqntyfdffnyaglqrsvllyttpttyidditvttsveqdsglvnyqisvkgsnlfklev
rlldaenkvvangtgtqgqlkvpgvslwwpylmherpaylyslevqltaqtslgpvsdfy
tlpvgirtvavtksqflingkpfyfhgvnkhedadirgkgfdwpllvkdfnllrwlgana
frtshypyaeevmqmcdrygivvidecpgvglalpqffnnvslhhhmqvmeevvrrdknh
pavvmwsvanepashlesagyylkmviahtksldpsrpvtfvsnsnyaadkgapyvdvic
lnsyyswyhdyghleliqlqlatqfenwykkyqkpiiqseygaetiagfhqdpplmftee
yqkslleqyhlgldqkrrkyvvgeliwnfadfmteqsptrvlgnkkgiftrqrqpksaaf
llrerywkianet

    Sequence, based on observed residues (ATOM records): (download) 
    >3hn3E (E:)
lqggmlypqespsreckeldglwsfradfsdnrrrgfeeqwyrrplwesgptvdmpvpss
fndisqdwrlrhfvgwvwyerevilperwtqdlrtrvvlrigsahsyaivwvngvdtleh
eggylpfeadisnlvqvsrlritiainntltpttlppgtiqyltdtskypkgyfvqntyf
dffnyaglqrsvllyttpttyidditvttsveqdsglvnyqisvkgsnlfklevrlldae
nkvvangtgtqgqlkvpgvslwwpylmherpaylyslevqltaqtslgpvsdfytlpvgi
rtvavtksqflingkpfyfhgvnkhedadirgkgfdwpllvkdfnllrwlganafrtshy
pyaeevmqmcdrygivvidecpgvglalpqffnnvslhhhmqvmeevvrrdknhpavvmw
svanepashlesagyylkmviahtksldpsrpvtfvsnsnyaadkgapyvdviclnsyys
wyhdyghleliqlqlatqfenwykkyqkpiiqseygaetiagfhqdpplmfteeyqksll
eqyhlgldqkrrkyvvgeliwnfadfmteqsptrvlgnkkgiftrqrqpksaafllrery
wkiane