PDB entry 3hlb

View 3hlb on RCSB PDB site
Description: simvastatin synthase (lovd) from aspergillus terreus, unliganded, selenomethionyl derivative
Deposited on 2009-05-27, released 2009-10-27
The last revision was dated 2021-10-13, with a file datestamp of 2021-10-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transesterase
    Species: Aspergillus terreus [TaxId:33178]
    Gene: lovD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y7D1 (19-431)
      • expression tag (0-18)
      • engineered mutation (58)
      • engineered mutation (78)
  • Chain 'B':
    Compound: Transesterase
    Species: Aspergillus terreus [TaxId:33178]
    Gene: lovD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y7D1 (19-431)
      • expression tag (0-18)
      • engineered mutation (58)
      • engineered mutation (78)
  • Chain 'C':
    Compound: Transesterase
    Species: Aspergillus terreus [TaxId:33178]
    Gene: lovD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y7D1 (19-431)
      • expression tag (0-18)
      • engineered mutation (58)
      • engineered mutation (78)
  • Chain 'D':
    Compound: Transesterase
    Species: Aspergillus terreus [TaxId:33178]
    Gene: lovD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y7D1 (19-431)
      • expression tag (0-18)
      • engineered mutation (58)
      • engineered mutation (78)
  • Heterogens: SO4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3hlbA (A:)
gsshhhhhhssglvprgshmgsiidaaaaadpvvlmetafrkavksrqipgavimardas
gnlnytrcfgartvrrdennqlpplqvdtpcrlasatkllttimalqcmerglvdldetv
drllpdlsampvlegfddagnarlrerrgkitlrhllthtsglsyvflhpllreymaqgh
lqsaekfgiqsrlappavndpgaewiyganldwagklveratgldleqylqenicaplgi
tdmtfklqqrpdmlarradqthrnsadgrlryddsvyfradgeecfggqgvfsgpgsymk
vlhsllkrdglllqpqtvdlmfqpaleprleeqmnqhmdasphinyggpmpmvlrrsfgl
ggiialedldgenwrrkgsltfgggpnivwqidpkaglctlaffqlepwndpvcrdltrt
fehaiyaqyqqg

    Sequence, based on observed residues (ATOM records):
    >3hlbA (A:)
aadpvvlmetafrkavksrqipgavimardasgnlnytrcfgartvrrdennqlpplqvd
tpcrlasatkllttimalqcmerglvdldetvdrllpdlsampvlegfddagnarlrerr
gkitlrhllthtsglsyvflhpllreymaqghlqsaekfgiqsrlappavndpgaewiyg
anldwagklveratgldleqylqenicaplgitdmtfklqqrpdmlarradqthrnsadg
rlryddsvyfradgeecfggqgvfsgpgsymkvlhsllkrdglllqpqtvdlmfqpalep
rleeqmnqhmdasphinyggpmpmvlrrsfglggiialedldgenwrrkgsltfgggpni
vwqidpkaglctlaffqlepwndpvcrdltrtfehaiyaqyqqg

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3hlbB (B:)
gsshhhhhhssglvprgshmgsiidaaaaadpvvlmetafrkavksrqipgavimardas
gnlnytrcfgartvrrdennqlpplqvdtpcrlasatkllttimalqcmerglvdldetv
drllpdlsampvlegfddagnarlrerrgkitlrhllthtsglsyvflhpllreymaqgh
lqsaekfgiqsrlappavndpgaewiyganldwagklveratgldleqylqenicaplgi
tdmtfklqqrpdmlarradqthrnsadgrlryddsvyfradgeecfggqgvfsgpgsymk
vlhsllkrdglllqpqtvdlmfqpaleprleeqmnqhmdasphinyggpmpmvlrrsfgl
ggiialedldgenwrrkgsltfgggpnivwqidpkaglctlaffqlepwndpvcrdltrt
fehaiyaqyqqg

    Sequence, based on observed residues (ATOM records):
    >3hlbB (B:)
aadpvvlmetafrkavksrqipgavimardasgnlnytrcfgartvrrdennqlpplqvd
tpcrlasatkllttimalqcmerglvdldetvdrllpdlsampvlegfddagnarlrerr
gkitlrhllthtsglsyvflhpllreymaqghlqsaekfgiqsrlappavndpgaewiyg
anldwagklveratgldleqylqenicaplgitdmtfklqqrpdmlarradqthrnsadg
rlryddsvyfradgeecfggqgvfsgpgsymkvlhsllkrdglllqpqtvdlmfqpalep
rleeqmnqhmdasphinyggpmpmvlrrsfglggiialedldgenwrrkgsltfgggpni
vwqidpkaglctlaffqlepwndpvcrdltrtfehaiyaqyqqg

  • Chain 'C':
    Sequence, based on SEQRES records:
    >3hlbC (C:)
gsshhhhhhssglvprgshmgsiidaaaaadpvvlmetafrkavksrqipgavimardas
gnlnytrcfgartvrrdennqlpplqvdtpcrlasatkllttimalqcmerglvdldetv
drllpdlsampvlegfddagnarlrerrgkitlrhllthtsglsyvflhpllreymaqgh
lqsaekfgiqsrlappavndpgaewiyganldwagklveratgldleqylqenicaplgi
tdmtfklqqrpdmlarradqthrnsadgrlryddsvyfradgeecfggqgvfsgpgsymk
vlhsllkrdglllqpqtvdlmfqpaleprleeqmnqhmdasphinyggpmpmvlrrsfgl
ggiialedldgenwrrkgsltfgggpnivwqidpkaglctlaffqlepwndpvcrdltrt
fehaiyaqyqqg

    Sequence, based on observed residues (ATOM records):
    >3hlbC (C:)
aadpvvlmetafrkavksrqipgavimardasgnlnytrcfgartvrrdennqlpplqvd
tpcrlasatkllttimalqcmerglvdldetvdrllpdlsampvlegfddagnarlrerr
gkitlrhllthtsglsyvflhpllreymaqghlqsaekfgiqsrlappavndpgaewiyg
anldwagklveratgldleqylqenicaplgitdmtfklqqrpdmlarradqthrnsadg
rlrydddgeecfggqgvfsgpgsymkvlhsllkrdglllqpqtvdlmfqpaleprleeqm
nqhmdasphinyggpmpmvlrrsfglggiialedldgenwrrkgsltfgggpnivwqidp
kaglctlaffqlepwndpvcrdltrtfehaiyaqyqqg

  • Chain 'D':
    Sequence, based on SEQRES records:
    >3hlbD (D:)
gsshhhhhhssglvprgshmgsiidaaaaadpvvlmetafrkavksrqipgavimardas
gnlnytrcfgartvrrdennqlpplqvdtpcrlasatkllttimalqcmerglvdldetv
drllpdlsampvlegfddagnarlrerrgkitlrhllthtsglsyvflhpllreymaqgh
lqsaekfgiqsrlappavndpgaewiyganldwagklveratgldleqylqenicaplgi
tdmtfklqqrpdmlarradqthrnsadgrlryddsvyfradgeecfggqgvfsgpgsymk
vlhsllkrdglllqpqtvdlmfqpaleprleeqmnqhmdasphinyggpmpmvlrrsfgl
ggiialedldgenwrrkgsltfgggpnivwqidpkaglctlaffqlepwndpvcrdltrt
fehaiyaqyqqg

    Sequence, based on observed residues (ATOM records):
    >3hlbD (D:)
aadpvvlmetafrkavksrqipgavimardasgnlnytrcfgartvrrdennqlpplqvd
tpcrlasatkllttimalqcmerglvdldetvdrllpdlsampvlegfddagnarlrerr
gkitlrhllthtsglsyvflhpllreymaqghlqsaekfgiqsrlappavndpgaewiyg
anldwagklveratgldleqylqenicaplgitdmtfklqqrpdmlarradqthrnsadg
rlrydcfggqgvfsgpgsymkvlhsllkrdglllqpqtvdlmfqpaleprleeqmnqhmd
asphinyggpmpmvlrrsfglggiialedldgenwrrkgsltfgggpnivwqidpkaglc
tlaffqlepwndpvcrdltrtfehaiyaqyqqg