PDB entry 3hg1

View 3hg1 on RCSB PDB site
Description: Germline-governed recognition of a cancer epitope by an immunodominant human T cell receptor
Deposited on 2009-05-13, released 2009-07-28
The last revision was dated 2014-04-09, with a file datestamp of 2014-04-04.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.229
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MHC class I antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
  • Chain 'C':
    Compound: cancer/mart-1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3HG1 (0-9)
  • Chain 'D':
    Compound: T-cell receptor, alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3HG1 (0-193)
  • Chain 'E':
    Compound: T-cell receptor, beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3HG1 (0-243)
  • Heterogens: GOL, SO4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records:
    >3hg1A (A:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwep

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >3hg1B (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >3hg1C (C:)
elagigiltv

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >3hg1D (D:)
qeveqnsgplsvpegaiaslnctysdrgsqsffwyrqysgkspelimfiysngdkedgrf
taqlnkasqyvsllirdsqpsdsatylcavnvagkstfgdgttltvkpniqnpdpavyql
rdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfa
canafnnsiipedt

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records:
    >3hg1E (E:)
sqtihqwpatlvqpvgsplslectvegtsnpnlywyrqaagrglqllfysvgigqissev
pqnlsasrpqdrqfilsskklllsdsgfylcawsetglgtgelffgegsrltvledlknv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeq
palndsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
grad