PDB entry 3hcp

View 3hcp on RCSB PDB site
Description: Human ferrochelatase with Mn and deuteroporphyrin bound
Class: lyase
Keywords: ferrochelatase, metal selectivity, Disease mutation, Heme biosynthesis, Iron, Iron-sulfur, Lyase, Membrane, Metal-binding, Mitochondrion, Mitochondrion inner membrane, Porphyrin biosynthesis, Transit peptide
Deposited on 2009-05-06, released 2009-11-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.172
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ferrochelatase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: FECH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3hcpa_
  • Chain 'B':
    Compound: Ferrochelatase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: FECH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22830 (0-358)
      • variant (45)
    Domains in SCOPe 2.07: d3hcpb_
  • Heterogens: FES, CHD, GOL, IMD, FDE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3hcpA (A:)
rkpktgilmlnmggpetlgdvhdfllrlfldrdlmtlpiqnklapaiakrrtpkiqeqyr
rigggspikiwtskqgegmvklldelspntaphkyyigfryvhplteeaieemerdgler
aiaftqypqyscsttgsslnaiyryynqvgrkptmkwstidrwpthhlliqcfadhilke
ldhfplekrsevvilfsahslpmsvvnrgdpypqevsatvqkvmerleycnpyrlvwqsk
vgpmpwlgpqtdesikglcergrknillvpiaftsdhietlyeldieysqvlakecgven
irraeslngnplfskaladlvhshiqsnelcskqltlscplcvnpvcretksfftsqql

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3hcpB (B:)
rkpktgilmlnmggpetlgdvhdfllrlfldrdlmtlpiqnklapaiakrrtpkiqeqyr
rigggspikiwtskqgegmvklldelspntaphkyyigfryvhplteeaieemerdgler
aiaftqypqyscsttgsslnaiyryynqvgrkptmkwstidrwpthhlliqcfadhilke
ldhfplekrsevvilfsahslpmsvvnrgdpypqevsatvqkvmerleycnpyrlvwqsk
vgpmpwlgpqtdesikglcergrknillvpiaftsdhietlyeldieysqvlakecgven
irraeslngnplfskaladlvhshiqsnelcskqltlscplcvnpvcretksfftsqql