PDB entry 3h6o

View 3h6o on RCSB PDB site
Description: activator-bound structure of human pyruvate kinase m2
Deposited on 2009-04-23, released 2009-05-05
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate kinase isozymes M1/M2
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM2, PK2, PK3, PKM
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Pyruvate kinase isozymes M1/M2
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM2, PK2, PK3, PKM
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Pyruvate kinase isozymes M1/M2
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM2, PK2, PK3, PKM
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Pyruvate kinase isozymes M1/M2
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM2, PK2, PK3, PKM
    Database cross-references and differences (RAF-indexed):
  • Heterogens: FBP, UNX, D8G, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3h6oA (A:)
mgsshhhhhhssglvprgsmskphseagtafiqtqqlhaamadtflehmcrldidsppit
arntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasd
pilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldy
knickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpav
sekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfd
eileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprpt
raegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrl
apitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtar
qahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgf
tntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >3h6oA (A:)
qtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvar
lnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtgitlcdenilwl
dyknickvvevgskiyvddglislqvkqkgadflvtevengggskkgvnlpgaavdlpav
sekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfd
eileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprpt
raegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrl
apitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtar
qahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgf
tntmrvvpvp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3h6oB (B:)
mgsshhhhhhssglvprgsmskphseagtafiqtqqlhaamadtflehmcrldidsppit
arntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasd
pilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldy
knickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpav
sekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfd
eileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprpt
raegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrl
apitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtar
qahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgf
tntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >3h6oB (B:)
qtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvar
lnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtgliaevelkkga
tlkitldnaymekcdenilwldyknickvvevgskiyvddglislqvkqkgadflvteve
nggslgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvl
gekgknikiiskienhegvrrfdeileasdgimvargdlgieipaekvflaqkmmigrcn
ragkpvicatqmlesmikkprptraegsdvanavldgadcimlsgetakgdypleavrmq
hliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiivltksgrsa
hqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgk
argffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'C':
    Sequence, based on SEQRES records:
    >3h6oC (C:)
mgsshhhhhhssglvprgsmskphseagtafiqtqqlhaamadtflehmcrldidsppit
arntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasd
pilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldy
knickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpav
sekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfd
eileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprpt
raegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrl
apitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtar
qahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgf
tntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >3h6oC (C:)
qtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvar
lnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtdenilwldykni
ckvvevgskiyvddglislqengggvnlpgaavdlpavsekdiqdlkfgveqdvdmvfas
firkasdvhevrkvlgekgknikiiskienhegvrrfdeileasdgimvargdlgieipa
ekvflaqkmmigrcnragkpvicatqmlesmikkprptraegsdvanavldgadcimlsg
etakgdypleavrmqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkc
csgaiivltksgrsahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawa
edvdlrvnfamnvgkargffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'D':
    Sequence, based on SEQRES records:
    >3h6oD (D:)
mgsshhhhhhssglvprgsmskphseagtafiqtqqlhaamadtflehmcrldidsppit
arntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasd
pilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldy
knickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpav
sekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfd
eileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprpt
raegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrl
apitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtar
qahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgf
tntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >3h6oD (D:)
qtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvar
lnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtelkkgatlkitl
dnaymekcdenilwldyknickvvevgskiyvddglislqvkqkgadflvtevenggslg
skkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgkn
ikiiskienhegvrrfdeileasdgimvargdlgieipaekvflaqkmmigrcnragkpv
icatqmlesmikkprptraegsdvanavldgadcimlsgetakgdypleavrmqhliare
aeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiivltksgrsahqvary
rprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffk
kgdvvivltgwrpgsgftntmrvvpvp