PDB entry 3h4g

View 3h4g on RCSB PDB site
Description: Structure of aldehyde reductase holoenzyme in complex with potent aldose reductase inhibitor Fidarestat: Implications for inhibitor binding and selectivity
Class: oxidoreductase
Keywords: TIM BARREL, ALDO-KETO REDUCTASE, TERNARY COMPLEX, NADP, Oxidoreductase
Deposited on 2009-04-20, released 2009-05-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-05-05, with a file datestamp of 2009-05-01.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.185
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Alcohol dehydrogenase [NADP+]
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P50578 (0-End)
      • see remark 999 (60)
      • see remark 999 (270)
    Domains in SCOPe 2.08: d3h4ga_
  • Heterogens: SO4, NAP, FID, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3h4gA (A:)
maascvllhtgqkmpliglgtwksepgqvkaaikyaltvgyrhidcaaiygneleigeal
qetvgpgkavpreelfvtsklwntkhhpedvepalrktladlqleyldlylmhwpyafer
gdnpfpknadgtirydathykdtwkalealvakglvralglsnfssrqiddvlsvasvrp
avlqvechpylaqneliahcqarglevtaysplgssdrawrdpnepvlleepvvqalaek
ynrspaqillrwqvqrkvicipksvtpsrilqniqvfdftfspeemkqldalnknlrfiv
pmltvdgkrvprdaghplypfndpy

    Sequence, based on observed residues (ATOM records): (download) 
    >3h4gA (A:)
maascvllhtgqkmpliglgtwksepgqvkaaikyaltvgyrhidcaaiygneleigeal
qetvgpgkavpreelfvtsklwntkhhpedvepalrktladlqleyldlylmhwpyafer
gdnpfpknadgtirydathykdtwkalealvakglvralglsnfssrqiddvlsvasvrp
avlqvechpylaqneliahcqarglevtaysplgssdrawrdpnepvlleepvvqalaek
ynrspaqillrwqvqrkvicipksvtpsrilqniqvfdftfspeemkqldalnknlrfiv
pmltrvprdaghplypfndp