PDB entry 3h44

View 3h44 on RCSB PDB site
Description: crystal structure of insulin degrading enzyme in complex with macrophage inflammatory protein 1 alpha
Deposited on 2009-04-17, released 2010-04-14
The last revision was dated 2021-10-13, with a file datestamp of 2021-10-08.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.185
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Gene: IDE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735 (12-989)
      • expression tag (0-11)
      • engineered mutation (80-81)
      • engineered mutation (141)
      • engineered mutation (148)
      • engineered mutation (227)
      • engineered mutation (384)
      • engineered mutation (543)
      • engineered mutation (560)
      • engineered mutation (759)
      • engineered mutation (782)
      • engineered mutation (789)
      • engineered mutation (874)
      • engineered mutation (936)
      • engineered mutation (944)
  • Chain 'B':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Gene: IDE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735 (12-989)
      • expression tag (0-11)
      • engineered mutation (80-81)
      • engineered mutation (141)
      • engineered mutation (148)
      • engineered mutation (227)
      • engineered mutation (384)
      • engineered mutation (543)
      • engineered mutation (560)
      • engineered mutation (759)
      • engineered mutation (782)
      • engineered mutation (789)
      • engineered mutation (874)
      • engineered mutation (936)
      • engineered mutation (944)
  • Chain 'C':
    Compound: C-C motif chemokine 3
    Species: Homo sapiens [TaxId:9606]
    Gene: CCL3, G0S19-1, MIP1A, MIP1alpha, SCYA3
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: C-C motif chemokine 3
    Species: Homo sapiens [TaxId:9606]
    Gene: CCL3, G0S19-1, MIP1A, MIP1alpha, SCYA3
    Database cross-references and differences (RAF-indexed):
  • Heterogens: DIO, ZN, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3h44A (A:)
mhhhhhhaagipmnnpaikrignhitkspedkreyrglelangikvllisdpttdkssaa
ldvhigslsdppniaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtny
yfdvshehlegaldrfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatg
npkhpfskfgtgnkytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltn
lvvklfsevenknvplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksn
pghylghlighegpgsllselkskgwvntlvggqkegargfmffiinvdlteegllhved
iilhmfqyiqklraegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleev
ltaeylleefrpdliemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdev
ikkwqnadlngkfklptknefiptnfeilplekeatpypalikdtamsklwfkqddkffl
pkanlnfeffspfayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmyl
svkgyndkqpillkkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrll
mtevawtkdelkealddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtl
iehahtkpllpsqlvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmfle
lfaqiisepafntlrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflit
meksiedmteeafqkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylk
tltkediikfykemlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqp
eviqnmtefkrglplfplvkphinfmaakl

    Sequence, based on observed residues (ATOM records):
    >3h44A (A:)
nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
iaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
mlavdaprrhkvsvhvlaremdsnlsqapalpqpeviqnmtefkrglplfplvkph

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3h44B (B:)
mhhhhhhaagipmnnpaikrignhitkspedkreyrglelangikvllisdpttdkssaa
ldvhigslsdppniaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtny
yfdvshehlegaldrfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatg
npkhpfskfgtgnkytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltn
lvvklfsevenknvplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksn
pghylghlighegpgsllselkskgwvntlvggqkegargfmffiinvdlteegllhved
iilhmfqyiqklraegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleev
ltaeylleefrpdliemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdev
ikkwqnadlngkfklptknefiptnfeilplekeatpypalikdtamsklwfkqddkffl
pkanlnfeffspfayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmyl
svkgyndkqpillkkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrll
mtevawtkdelkealddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtl
iehahtkpllpsqlvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmfle
lfaqiisepafntlrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflit
meksiedmteeafqkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylk
tltkediikfykemlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqp
eviqnmtefkrglplfplvkphinfmaakl

    Sequence, based on observed residues (ATOM records):
    >3h44B (B:)
nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
iaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
mlavdaprrhkvsvhvlaremdnlsqapalpqpeviqnmtefkrglplfplvkph

  • Chain 'C':
    Sequence, based on SEQRES records:
    >3h44C (C:)
aslaadtptaccfsytsrqipqnfiadyfetssqcskpgvifltkrsrqvcadpseewvq
kyvsdlelsa

    Sequence, based on observed residues (ATOM records):
    >3h44C (C:)
aslakrsrqv

  • Chain 'D':
    Sequence, based on SEQRES records:
    >3h44D (D:)
aslaadtptaccfsytsrqipqnfiadyfetssqcskpgvifltkrsrqvcadpseewvq
kyvsdlelsa

    Sequence, based on observed residues (ATOM records):
    >3h44D (D:)
aslasrqv