PDB entry 3h22

View 3h22 on RCSB PDB site
Description: Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
Class: Transferase/Transferase Inhibitor
Keywords: ANTHRACIS, FOLATE BIOSYNTHESIS, DIHYDROPTEROATE, PTERINE, Transferase, Transferase-Transferase Inhibitor COMPLEX
Deposited on 2009-04-14, released 2009-12-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.223
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydropteroate synthase
    Species: Bacillus anthracis str. A2012 [TaxId:191218]
    Gene: folP, BAO_0074
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3h22a_
  • Chain 'B':
    Compound: dihydropteroate synthase
    Species: Bacillus anthracis str. A2012 [TaxId:191218]
    Gene: folP, BAO_0074
    Database cross-references and differences (RAF-indexed):
    • Uniprot B1UXN2 (20-End)
      • expression tag (3-16)
    Domains in SCOPe 2.06: d3h22b1, d3h22b2
  • Heterogens: B53, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3h22A (A:)
mgsshhhhhhssglvprgshmkwdydlrcgeytlnlnektlimgilnvtpdsfsdggsyn
evdaavrhakemrdegahiidiggestrpgfakvsveeeikrvvpmiqavskevklpisi
dtykaevakqaieagahiindiwgakaepkiaevaahydvpiilmhnrdnmnyrnlmadm
iadlydsikiakdagvrdeniildpgigfaktpeqnleamrnleqlnvlgypvllgtsrk
sfighvldlpveerlegtgatvclgiekgcefvrvhdvkemsrmakmmdamigkgvk

    Sequence, based on observed residues (ATOM records): (download) 
    >3h22A (A:)
kwdydlrcgeytlnlnektlimgilnvtpdsfggsynevdaavrhakemrdegahiidig
gsveeeikrvvpmiqavskevklpisidtykaevakqaieagahiindiwgakaepkiae
vaahydvpiilmhnrdnmnyrnlmadmiadlydsikiakdagvrdeniildpgigfaktp
eqnleamrnleqlnvlgypvllgtsrksfighvldlpveerlegtgatvclgiekgcefv
rvhdvkemsrmakmmdamigk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3h22B (B:)
mgsshhhhhhssglvprgshmkwdydlrcgeytlnlnektlimgilnvtpdsfsdggsyn
evdaavrhakemrdegahiidiggestrpgfakvsveeeikrvvpmiqavskevklpisi
dtykaevakqaieagahiindiwgakaepkiaevaahydvpiilmhnrdnmnyrnlmadm
iadlydsikiakdagvrdeniildpgigfaktpeqnleamrnleqlnvlgypvllgtsrk
sfighvldlpveerlegtgatvclgiekgcefvrvhdvkemsrmakmmdamigkgvk

    Sequence, based on observed residues (ATOM records): (download) 
    >3h22B (B:)
shhhhhhssglvprmkwdydlrcgeytlnlnektlimgilnvtggsynevdaavrhakem
rdegahiidiggevsveeeikrvvpmiqavskevklpisidtykaevakqaieagahiin
diwgakaepkiaevaahydvpiilmhnrdnmnyrnlmadmiadlydsikiakdagvrden
iildpgigfaktpeqnleamrnleqlnvlgypvllgtsrksfighvldlpveerlegtga
tvclgiekgcefvrvhdvkemsrmakmmdamigk